Modified oligonucleotides and applications thereof

Details Modified oligonucleotides and applications thereof Modified oligonucleotides and applications thereof

2005-04-14

2008-08-05

Riley, Jezia (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024300, C536S024330, C536S026600, C435S006120

Reexamination Certificate

active

07408051

ABSTRACT:
Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification reactions, and various methods of use thereof.

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Egholm, M. et al., “Efficient pH-Independent Sequence-Specific DNA Binding By Pseudoisocytosine-Containing Bis-PNA”, Nucleic Acids research, Oxford University Press, Surrey, GB, vol. 23(2), pp. 217-222 (1995).
Nielsen, Peter E., “Targeting Double Stranded DNA with Peptide Nucleic Aid (PNA)”, Current Medicinal Chemistry, vol. 8, pp. 545-549 (2001).
Ono, A. et al., “Triplex Formation Oligonucleotides Containing 2′-O-Methylpseudoisocytidine in Substitution for 2′Deoxycytidine”, Journal of the American Chemical Society, American Chemical Society, Washington, D.C., vol. 113, pp. 4032-4033 (1991).
Ono, A. et al., “Triplex Formation of an Oligonucleotide Containing 2′-O-Methylpseudoisocytidine with a DNA Duplex at Neural pH,” Journal of Organic Chemistry, American Chemical Society, Easton, PA, vol. 57(11), pp. 3225-3230 (1992).
Copy of Int'l Search Report & Written Opinion for Intl. Patent Application No. PCT/US2005/012570 mailed Nov. 9, 2006.

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