Modified oligodeoxyribonucleoditides

Details Modified oligodeoxyribonucleoditides Modified oligodeoxyribonucleoditides

1995-02-23

1997-10-07

Elliott, George C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 241, 536 245, 536 253, A61K 4800, C07H 2102, C07H 2104

Patent

active

056748566

ABSTRACT:
Compounds for the treatment or prophylaxis of a viral infection in a mammal, which may be human, are provided. The compounds are oligodeoxyribonucleic acid derivatives, and a novel route to such compounds is also provided together with intermediates of more general utility.
The active compounds are of the general formula (1): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms, alkyl groups, aryl groups as defined, and anthraquinonyl groups as defined; Z is carbon or silicon; or R.sub.2, R.sub.3 and Z together represent fluorenyl or xanthenyl; R.sub.4 is a hydrogen atom, an alkyl group as defined, an aryl group as defined; Y.sub.1, Y.sub.3 and Y.sub.4 are oxygen, sulfur or >NH; Y.sub.2 is oxygen, sulfur, >NH, alkylene or phenylene; X is alkylene group as defined; m and n are 0 to 10; and B is an oligodeoxyribonucleotide of chain length 3 to 9; or salts thereof.

REFERENCES:
patent: 5220003 (1993-06-01), Jung et al.
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Journal of the Chemical Society, Chemical Communications, vol. 12, 1982, pp. 672-674, C. Gioeli et al, "The Fluoren-9-ylmethoxycarbonyl Group for the Protection of Hydroxy Groups: Its Application in the Synthesis of an Octathymidylic Acid Fragment".
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