Modified MscL protein channel

Details Modified MscL protein channel Modified MscL protein channel

2006-05-19

2008-07-01

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C530S300000, C530S324000, C530S408000

Reexamination Certificate

active

07393828

ABSTRACT:
The invention relates to the field of drug delivery, in particular, to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles for controlled and/or localized release of therapeutic molecules (e.g., small molecules, peptides, proteins or other macromolecules). Provided are pH- and/or light-responsive compounds capable of controlling the channel activity of a mechanosensitive channel, such as the MscL channel protein ofE. coli, or a functional equivalent thereof, and use of these compounds to convert a mechanosensitive channel protein into a pH- and/or light-responsive channel. Also provided are drug delivery vehicles comprising a pH- and/or light-responsive channel protein.

REFERENCES:
patent: WO 2005/051902 (2005-06-01), None
Medical Dictionary for different channels.
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