Modified mite allergen and pharmaceutical uses thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S023100

Reexamination Certificate

active

07655782

ABSTRACT:
The present invention provides a modifiedDermatophagoides pteronyssinusallergen Der p 5 protein which has ability to inhibit IgE binding when exposed against to the antigen. A method for treating allergy comprising administrating a therapeutically effective dose of the modifiedD. pteronyssinusallergen Der p 5 protein to a subject suffering from allergy Der p 5 is also provided.

REFERENCES:
patent: 6187311 (2001-02-01), Nishiyama et al.
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Beezhold et al., “Mutational analysis of the IgE epitopes in the latex allergen Hev b 5”,J. Allergy Clin Immunol, Jun. 2001, pp. 1069-1076, vol. 107, No. 6.
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Cell Proliferation ELISA, BrdU (colorimetric). Colorimetric immunoassay for the quantification of cell proliferation, based on the measurement of BrdU incorporation during DNA synthesis: A non-radioactive alternative to the [3H]-thymidine incorporation assay. Cat. No. 1647229, 1 kit [1000 tests]. Instruction Manual. Version 4, Dec. 2001.
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Niu et al., Respiratory Medicine, Epub on Jan. 3, 2006, 10 pages.
QuikChange Site-Directed Mutagenesis Kit. Instruction Manual. Catalog #200518 (30 reactions) and #200519 (10 reactions). Revision #0582008g, 2002.

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