Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1985-10-01
1988-02-23
Kight, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530350, 530403, 530405, 530806, 530825, 424 88, 424 92, 536 11, 514 23, C07K 1504, C07K 39095, C07K 39108, C07H 100
Patent
active
047271361
ABSTRACT:
The group B polysaccharide of Neisseria meningitidis is chemically modified to enhance the immune response thereto, thereby providing cross-reactive antibodies of high affinity. The N-acetyl group of the sialic acid residues of the polysaccharide has been substituted by the N-propionyl group, and this modified antigen then conjugated to a physiologically-acceptable protein such as tetanus toxoid. This conjugate vaccine has been found to raise high titers of high affinity group B IgG antibodies and would be useful against meningitis caused by group B N. meningitidis or by E. coli KI organisms.
REFERENCES:
patent: 4185090 (1980-01-01), McIntire
patent: 4356170 (1982-10-01), Jennings et al.
patent: 4545985 (1985-10-01), Pastan et al.
Jennings et al, I. Immunol., 134, 1985, pp. 2651-2657.
Lifely et al, Carbohydrate Res., 94, 1981, pp. 193-203.
Isai et al, J. Bacteriology, 146, 1981, pp. 69-78.
Frasch, Semin. Infert. Dis., 2, 1979, pp. 304-337.
Gamian Andrzej
Jennings Harold J.
Roy Rene
Canadian Patents and Development Ltd.
Draper Garnette D.
Kight John
Thomson Alan A.
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