Modified macromolescules and associated methods of synthesis...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S056000, C514S777000, C536S018700, C536S021000, C424S488000, C424S499000

Reexamination Certificate

active

07981871

ABSTRACT:
Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking by introduction of at least one hydrazide-reactive group and/or aminooxy-reactive group, and methods of making and using thereof for scar-free wound healing, for delivering bioactive agents or living cells, for preventing adhesion after a surgical procedure or for bone and cartilage repair. The macromolecule can be an oligonucleotide, a necleic acid, a polypeptide, a lipid, a glycoprotein, a glycolipid, a polysaccharide, a protein or a synthetic polymer, preferably a glycosaminoglycan like hyaluronan.

REFERENCES:
patent: 5135919 (1992-08-01), Folkman et al.
patent: 5290807 (1994-03-01), Folkman et al.
patent: 5504074 (1996-04-01), D'Amato et al.
patent: 5616568 (1997-04-01), Pouyani et al.
patent: 5639725 (1997-06-01), O'Reilly et al.
patent: 5652347 (1997-07-01), Pouyani et al.
patent: 5661143 (1997-08-01), D'Amato et al.
patent: 5698586 (1997-12-01), Kishimoto et al.
patent: 5733876 (1998-03-01), O'Reilly et al.
patent: 5792845 (1998-08-01), O'Reilly et al.
patent: 5854205 (1998-12-01), O'Reilly et al.
patent: 5854221 (1998-12-01), Cao et al.
patent: 5861372 (1999-01-01), Folkman et al.
patent: 5874417 (1999-02-01), Prestwich et al.
patent: 5885795 (1999-03-01), O'Reilly et al.
patent: 5892069 (1999-04-01), D'Amato et al.
patent: 5945403 (1999-08-01), Folkman et al.
patent: 6017954 (2000-01-01), Folkman et al.
patent: 6024688 (2000-02-01), Folkman et al.
patent: 6086865 (2000-07-01), Folkman et al.
patent: 6174861 (2001-01-01), O'Reilly et al.
patent: 6387978 (2002-05-01), Ronan et al.
patent: 6521223 (2003-02-01), Calias et al.
patent: 6534591 (2003-03-01), Rhee et al.
patent: 6548081 (2003-04-01), Sadozai et al.
patent: 6551610 (2003-04-01), Shalaby et al.
patent: 6562363 (2003-05-01), Mantelle et al.
patent: 6617450 (2003-09-01), Stocker et al.
patent: 6630457 (2003-10-01), Bulpitt et al.
patent: 6635622 (2003-10-01), Tomiyama et al.
patent: 6656714 (2003-12-01), Holmes et al.
patent: 2003/0087877 (2003-05-01), Calias et al.
patent: 0 045 665 (1985-09-01), None
patent: WO 02/06373 (2002-01-01), None
patent: WO 02/090390 (2002-11-01), None
patent: WO 2004/037164 (2004-05-01), None
Mironov, V., Prestwich, G., Forgacs, G. (2007) Bioprinting living structures. Journal of Materials Chemistry, vol. 17, p. 2054-2060.
Almquist et al., “Synthesis and biological activity of a ketomethylene analogue of a tripeptide inhibitor of angiotensin converting enzyme”,Journal of Medicinal Chemistry, 23:1392-1398 (1980).
Benner, S.A., “Expanding the genetic lexicon: incorporating non-standard amino acids into proteins by ribosome-based synthesis”,Trends in Biotechnology, 12:158-163 (1994).
Cahill et al. , “Site-Specific Mutagenesis with Unnatural Amino Acids.”Trends in Biochemical Sciences, 14(10):400-403 (1989).
The International Search report and Written Opinion for PCT application PCT/US2004/040726, search report dated Mar. 31, 2005, 8 pages (2005).
Hann J. et al., “On the Double Bond Isostere of the Peptide Bond: Preparation of an Enkephalin Analogue”,J.C.S. Perkin Trans 1, The Royal Society of Chemistry, 307-314 (1982).
Hennink and van Nostrum, “Novel crosslinking methods to design hydrogels”,Adv. Drug Del, Rev., 54:13-36 (2002).
Holladay et al., “Synthesis of Hydroxyethylene and Ketomethylene Dipeptide Isosteres”,Tetrahedron. Letters, 24(41):4401-4404 (1983).
Hruby, V.J., “Conformational restrictions of biologically active peptides via amino acid side chain groups”,Life Sciences, 31(3):189-199 (1982).
Hudson, D. et al., “Methionine enkephalin and isosteric analogues. I. Synthesis on a phenolic resin support”,International Journal of Peptide and Protein Research, 14(3):177-185 (1979).
Ibba and Hennecke, “Towards engineering proteins by site-directed incorporation in vivo of non-natural amino acids”,Biotechnology, 12(7): 678-682 (1994).
Ibba, “Strategies for in vitro and in vivo translation with non-natural amino acids”,Biotechnology&Genetic Enginerring Reviews, 13:197-216 (1995).
Jaeger et al. “Predicting optimal and suboptimal secondary structure for RNA”,Methods Enzymology, 183:281-306 (1989).
Jaeger, J.A. et al., “Improved predictions of secondary structures for RNA”,Proc. Natl. Acad. Sci. USA, 86(20):7706-7710 (1989).
Jennings-White and Almquisr, R.G., “Synthesis of Ketomethylene Analogs of Dipeptides”,Tetrahedron Letters, 23(25): 2533-2534 (1982).
Jones, D.S. et al., “Multivalent poly(ethylene glycol)-containing conjugates for in vivo antibody suppression”,Bioconjugate Chem, 14(6):1067-1076 (2003).
Letsinger, R.L. et al., “Cholesteryl-conjugated oligonucleotides: synthesis, properties, and activity as inhibitors of replication of human immunodeficiency virus in cell culture”,Proc Nat Acad Sci USA, 86(17):6553-6556 (1989).
Morley, J., “K+ channel openers and suppression of airway hyperreactivity”,Trends Pharm Sci., 15(12):463-468 (1994).
Needleman and Wunsch, “A general method applicable to the search for similarities in the amino acid sequence of two proteins”,J. MoL Biol., 48(3):443-453 (1970).
Pearson and Lipman, “Improved tools for biological sequence comparison”,Proc. Natl. Acad. Sci. U. S. A., 85(8): 2444-2448 (1988).
Rizo and Gierasch, “Constrained peptides: models of bioactive peptides and protein substructures”,Ann. Rev. Biochem., 61:387-418 (1992).
Smith, T.F. and Waterman, M.S., “Comparison of Biosequences”,Advances in Applied Mathematics, 2: 482-489 (1981).
Spatola, A.F. et al., “Structure-activity relationships of enkephalins containing serially replaced thiomethylene amide bond surrogates”,Life Sciences, 38 :1243-1249 (1986).
Spatola, A. F. in Chemistry and Biochemistry of Amino Acids, Peptides, and Proteins, B. Weinstein, eds. , Marcel Dekker, New York, Chapter 5, pp. 267-319 (1983).
T. E. Creighton,Proteins: Structure and Molecular Properties, “Posttranslational Covalent Modifications of Polypeptide Chains”, W. H. Freeman & Co. , San Francisco pp. 78-86 (1983).
Thorson et al., “A Biosynthetic Approach for the Incorporation of Unnatural Amino Acids into Proteins”,Methods in Molecular Biology, 77:43-73 (1991).
Toyokuni, T. et al., “Synthesis of a new heterobifunctional linker, N-[4-(aminooxy)butyl]maleimide, for facile access to a thiol-reactive 18F-labeling agent”,Bioconjugate Chem, 14(6):1253-1259 (2003).
Zoller, M.J., “New recombinant DNA methodology for protein engineering”,Current Opinion in Biotechnology, 3(4):348-354 (1992).
Zuker, M., “On finding all suboptimal foldings of an RNA molecule”,Science, 244(4900):48-52 (1989).
Almquist et al., “Synthesis and biological activity of a ketomethylene analogue of a tripeptide inhibitor of angiotensin converting enzyme”,Journal of Medicinal Chemistry, 23:1392-1398 (1980).
Benner, S.A., “Expanding the genetic lexicon: incorporating non-standard amino acids into proteins by ribosome-based synthesis”,Trends in Biotechnology, 12:158-163 (1994).
Cahill et al. , “Site-Specific Mutagenesis with Unnatural Amino Acids.”Trends in Biochemical Sciences, 14(10):400-403 (1989).
Cao, Y. et al., “Comparative study of the use of poly(glycolic acid), calcium alginate and pluronics in the engineering of autologous porcine cartilage”,J. Biomaterials Sci. Polymer Edn., 9:475-487 (1998).
Chen, W.Y. and Abatangelo, G. “Functions of hyaluronan in wound repair”,Wound Repair and Regeneration, 7:79-89 (1999).
The International Search report and Written Opinion for PCT application PCT/US2004/040726, search report dated Mar. 31, 2005, 8 pages (2005).
Hann J. et al., “On the Double Bond Isostere of the Peptide Bond: Preparation of an Enkephalin Analogue”,J.C.S. Perkin Trans 1, The Royal Soci

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Modified macromolescules and associated methods of synthesis... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modified macromolescules and associated methods of synthesis..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified macromolescules and associated methods of synthesis... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2686514

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.