Modified lipopolysaccharides and process of preparation

Details Modified lipopolysaccharides and process of preparation Modified lipopolysaccharides and process of preparation

1988-06-29

1990-03-27

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536124, 536 11, 536119, 536117, 536115, 435101, C07H 100, C07H 1302, C07G 1700, C12P 1904

Patent

active

049120948

ABSTRACT:
Modified lipopolysaccharides, particularly de-3-0-acylated monophosphoryl lipid A and de-3-0-acylated diphosphoryl lipid A, are provided by an alkaline hydrolysis under controlled conditions which removes only the .beta.-hydroxymyristic acyl residue that is ester-linked to the reducing-end glucosamine at position 3. The modified products are less endotoxic and maintain their antigenic and immuno-stimulating properties.

REFERENCES:
patent: 3089821 (1963-05-01), Folkers
patent: 4029762 (1977-06-01), Galanos et al.
patent: 4185090 (1980-01-01), McIntire

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