Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-12-04
2007-12-04
Zeman, Robert A. (Department: 1645)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C435S252100, C435S320100, C435S410000
Reexamination Certificate
active
10148884
ABSTRACT:
The present invention provides nucleic acid sequences encoding a modified leukotoxin protein, wherein the modification comprises the removal of nucleic acid sequences encoding amino acids within hydrophobic transmembrane domains of full length leukotoxin protein, preferably fromMannheimia haemolytica. The modified leukotoxin proteins are useful in vaccine compositions effective againstMannheimia haemolyticain animals.
REFERENCES:
patent: 5143830 (1992-09-01), Holland et al.
patent: 5336491 (1994-08-01), Berget et al.
patent: 5476657 (1995-12-01), Potter
patent: 5849531 (1998-12-01), Potter
patent: 5871750 (1999-02-01), Potter
patent: 2014033 (1990-10-01), None
patent: WO 98/46260 (1998-10-01), None
patent: WO 99/15670 (1999-04-01), None
Bowie et al (Science, 1990, 257:1306-1310).
Greenspan et al. (Nature Biotechnology 7: 936-937, 1999).
Cruz, W.T. et al.: “Deletion analysis resolves cell-binding and lytic domains of the Pasteurella leukotoxin” Mol. Microbiol., vol. 4, No. 11, 1990, pp. 1993-1939, XP000993015.
Tatum, F. M. et al.: “Construction of an isogenic leukotoxin deletion mutant of Pasteurella haemolytica serotype 1: characterization and virulence” Microbial Pathogenesis, vol. 24, 1998, pp. 37-48, XP000993013.
Hodgins Doug
Lee Raymond W. H.
Lo Reggie Y.
Shewen Patricia E.
Strommer Judith N.
Bereskin & Parr
Gravelle Micheline
University of Guelph
Zeman Robert A.
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