Modified leukotoxin gene and protein

Chemistry: molecular biology and microbiology – Plant cell or cell line – per se ; composition thereof;... – Plant cell or cell line – per se – contains exogenous or...

Reexamination Certificate

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C536S023700, C424S184100

Reexamination Certificate

active

07932085

ABSTRACT:
The present invention provides nucleic acid sequences encoding a modified leukotoxin protein, wherein the modification comprises the removal of nucleic acid sequences encoding amino acids within hydrophobic transmembrane domains of full length leukotoxin protein, preferably fromMannheimia haemolytica. The modified leukotoxin proteins are useful in vaccine compositions effective againstMannheimia haemolyticain animals.

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