Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1991-11-21
1995-02-14
Hill, Jr., Robert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351721, 4353201, 435 694, 435 712, 536 231, 536 234, 935 48, C12N 1511
Patent
active
053895290
ABSTRACT:
Signal sequences based on LamB have been constructed. These signal sequences facilitate both the synthesis and secretion of neurotrophins in E. coli.
REFERENCES:
patent: 4511502 (1985-04-01), Builder et al.
patent: 4620948 (1986-11-01), Builder et al.
patent: 4680262 (1987-07-01), Bochner et al.
patent: 4734362 (1988-03-01), Hung et al.
patent: 4758512 (1988-07-01), Goldberg et al.
patent: 4961969 (1990-10-01), Hershenson et al.
Ip et al., 1992, "Mammalian Neurotrophin-4: Structure, Chromosomal Localization, Tissue Distribution, and Receptor Specificity," Proc. Natl. Acad. Sci. USA 89:3060-3064.
Stader et al., 1990, Methods In Enzymology, vol. 185 "Engineering Escherichia coli to Secrete Heterologous Gene Products", pp. 166-187.
Berkemeier et al., 1991, "Neurotrophin-5: A Novel Neurotrophin that activates trk and trkB": Neuron 7:857-866.
Chapter 4, p. 77, Biochemistry, Second Edition, "The Molecular Basis of Cell Structure and Function", Ed. A. L. Lehninger (1977).
Bruce, G., and G. Heinrich, 1989, "Production and Characterization of Biologically Active Recombinant Human Nerve Growth Factor," Neurobiology of Aging, 10:89-94.
Denefle, P., et al., 1989, "Heterologous Protein Export in Escherichia coli: Influence of Bacterial Signal Peptides on the Export of Human Interleukin 1.beta.," Gene, 85:499-510.
Dicou, E., et al., 1989, "Synthesis of Chimeric Mouse Nerve Growth Factor Precursor and Human .beta.-Nerve Growth Factor in Escherichia Coli: Immunological Properties," Journal of Neuroscience Research, 22:13-19.
Evan, G. I., et al., 1985, "Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product," Mol. Cell. Biol., 5:3610-16.
Fonnum, F. 1975, "A Rapid Radiochemical Method for the Determination of Choline Acetyltransferase," J. Neurochem., 24:407-409.
Goff, S. A., et al., 1984, "Heat Shock Regulatory Gene htpR Influences Rates of Protein Degradation and Expression of the Ion Gene in Escherichia coli," Proc. Natl. Acad. Sci. USA, 81:6647-51.
Halbook, F. et al., 1991, "Evolutionary Studies of the Nerve Growth Factor Family Reveal a Novel Member Abundantly Expressed in Xenopus Ovary," Neuron, 6:845-858.
Hedgpeth, J., et al., 1980, "DNA Sequence Encoding the NH.sub.2 Terminal Peptide Involved in Transport of .lambda. Receptor, an Escherichia coli Secretory Protein," Proc. Natl. Acad. Sci. USA, 77:2621-2625.
Hohn, A. et al., 1990, "Identification and Characterization of a Novel Member of The Nerve Growth Factor/Brain-Derived Neurotrophic Factory Family," Nature, 344:339-341.
Hu, G., et al., 1990, "Comparison of Expression and Folding of Mouse Recombinant .beta.-Nerve Growth Factor (NGF) in Bacterial Systems," Abstracts: Soc. for Neuroscience, 20th Ann. Mtg., 16:343.16.
Hu, G., and K. E. Neet, 1988, "Expression of the cDNA for Mouse .beta.-Nerve Growth Factor Protein in Escherichia coli,"Gene, 70:57-65.
Ibanez, C. F., et al., 1990, "Structure-function Studies of Nerve Growth Factor: Functional Importance of Highly Conserved Amino Acid Residues," EMBO J., 9:1477-83.
Iwai, S., et al., 1986, "Synthesis of Genes for Human Nerve Growth Factor and Its Fused Protein," Chem. Pharm. Bull., 34:4724-30.
Kaisho, Y., et al., 1990, "Cloning and Expression of a cDNA Encoding a Novel Human Neurotrophic Factor," FEBS Letters, 266:187-191.
Kanaya, E., et al., 1989, "Synthesis and Secretion of Human Nerve Growth Factor by Saccharomyces cerevisiae," Gene, 83:65-74.
Kawaguchi, Y., et al., 1984, "Renaturation and Activation of Calf Prochymosin Produced in an Insoluble Form in Escherichia coli," J. of Biotechnology, 1:307-315.
Leibrock, J., et al., 1989, "Molecular Cloning and Expression of Brain-derived Neurotrophic Factor," Nature, 341:149-52.
Maisonpierre, P. C., et al., 1990, "Neurotrophin-3: A Neurotrophic Factor Related to NGF and BDNF," Science, 247:1446-51.
Marston, F. A. O., et al., 1984, "Purification of Calf Prochymosin (Prorennin) Synthesized in Escherichia coli," Bio/Technology, Sep. 1984, pp. 800-804.
Meier, R. et al., 1986, "Molecular Cloning of Bovine and Chick Nerve Growth Factor (NGF): Delineation of Conserved and Unconserved Domains and their Relationship to the Biological Activity and Antigenicity of NGF," EMBO J., 5:1489-1493.
Miller, K. W., et al., 1989, "Secretory Leukocyte Protease Inhibitor Binding to mRNA and DNA as a Possible Cause of Tosicity to Escherichia coli," J. Bacteriol., 171(4):2166-72.
Obukowicz, M. G., et al., 1988, "Secretion and Export of IGF-1 in Escherichia coli Strain JM101," Mol. Gen. Genet., 215:19-25.
Panayotatos, N., 1987, "Engineering on Efficient Expression System," Plasmids-A Practical Approach, (Hardy, K., ed.), IRL Press, Oxford/Washington, D.C.
Rosenthal, A. et al., 1990, "Primary Structure and Biological Activity of a Novel Human Neurotrophic Factor," Neuron, 4:767-773.
Sambrook, J., et al., 1989, Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
Schwarz, M. A. et al., 1989, "Isolation and Sequence of a cDNA Clone of .beta.-Nerve Growth Factor From the Guinea Pig Prostate Gland," J. of Neurochemistry, 52:1203-1209.
Scott, J. et al., 1983, "Isolation and Nucleotide Sequence of a cDNA Encoding the Precursor of Mouse Nerve Growth Factor," Nature, 302:538-540.
Selby, M. J. et al., 1987, "Cobra Nerve Growth Factor: Structure and Evolutionary Comparison," J. of Neurosci. Res., 18:293-298.
Tsuji, T., et al., 1987, "Characterization of Disulfide Bonds in Recombinant Proteins: Reduced Human Interleukin 2 in Inclusion Bodies and Its Oxidative Refolding," Biochemistry, 26:3129-34.
Twigg, A. J., and D. Sherratt, 1980, "Trans-complementable Copy-Number Mutants of Plasmid ColE1," Nature, 283:216-18.
Ullrich, A., et al., 1983, "Human .beta.-nerve Growth Factor Gene Sequence Highly Homologous to That of Mouse," Nature, 303:821-25.
Wong, E. Y., et al., 1988, "Expression of Secreted Insulin-like Growth Factor-1 in Escherichia coli," Gene, 68:193-203.
Fandl James P.
Panayotatos Nikos
Hill Jr. Robert J.
Regeneron Pharmaceuticals Inc.
Spector Lorraine M.
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