Modified L-nucleic acid

Details Modified L-nucleic acid Modified L-nucleic acid

2002-10-25

2009-12-08

Vivlemore, Tracy (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C536S025300, C514S04400A

Reexamination Certificate

active

07629456

ABSTRACT:
The present invention relates to a modified L-nucleic acid, comprising a L-nucleic acid part and a non-L-nucleic acid part, whereby the L-nucleic acid part is conjugated to the non-L-nucleic acid part and the conjugation of the L-nucleic acid part with the non-L-nucleic acid past leads to a slowed elimination out of the organism, in comparison with a L-nucleic acid which only comprises the L-nucleic acid part, said L-nucleic acid part being a spiegelmer.

REFERENCES:
patent: 6051698 (2000-04-01), Janjic et al.
patent: WO 94/20523 (1994-09-01), None
patent: WO 98/08856 (1998-03-01), None
Klussmann et al. Nature Biotechnology 1996, vol. 14, pp. 1112-1115.
Nolte et al. Nature Biotechnology 1996, vol. 14, pp. 1116-1119.
Opalinska et al. Nature Reviews Drug Discovery 2002, vol. 1, pp. 503-514.
Asseline, U. et al. “Synthesis and Physicochemical Properties of Oligonucleotides Built with Either Alpha-L or Beta-L Nucleotides Units and Covalently Linked to an Acridine Derivative”, Nucleic Acids Research, vol. 19, No. 15, Oxford University Press, XP002920044, Aug. 1991, pp. 4067-4074.
Moyroud, E. et al. “Synthesis and Enzymatic Digestion of an RNA Nonamer in Both Enantiomeric Forms”, Tetrahedron, Elsevier Science Publishers, XP004203025, Amsterdam, NL, Mar. 2000, pp. 1475-1484.

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