Modified internucleoside linkages having one nitrogen and two ca

Details Modified internucleoside linkages having one nitrogen and two ca Modified internucleoside linkages having one nitrogen and two ca

1991-09-20

1997-01-21

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 243, 536 245, C07H 2100, C07H 2102, C07H 2104, A61K 3170

Patent

active

055960863

ABSTRACT:
Oligonucleotide analogs are disclosed wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by a backbone linkage resistant to nucleases. The modified oligonucleotides are capable of strong hybridization to target RNA or DNA. The oligomers of the invention may be used as diagnostic reagents to detect the presence or absence of the target DNA or RNA sequences to which they bind.

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