Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1993-02-04
1994-09-20
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
930141, 435 6952, 424 852, C07K 1300
Patent
active
053490517
ABSTRACT:
The present invention relates to modified forms of IL-1.beta. with altered IL-1.beta. activity. The modified IL-1.beta. is the result of mutations which affect amino acids in the beta barrel portion of the IL-1.beta. structural formula. The invention also relates to expression systems that will produce the modified IL-1.beta. polypeptides, and methods of treating susceptible diseases with the modified IL-1.beta. polypeptides.
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Draper Garnette D.
University of Maryland
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