Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Reexamination Certificate
2008-03-17
2009-11-10
Rao, Manjunath N (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
C530S350000, C424S085100, C435S069100
Reexamination Certificate
active
07615615
ABSTRACT:
The present invention relates a modified human interferon beta (INFβ) which is less immunogenic than human INFβ (SEQ ID NO: 1) when administered in vivo to a human. The modified human INFβ comprises an amino acid residue sequence that differs from SEQ ID NO: 1 by an amino acid residue substitution selected from the group consisting of L57A, L57C, L57D L57E, L57G, L57H, L57K, L57N, L57P, L57Q, L57R, L57S, and L57T and an additional substitution selected from the group consisting of the H140A, H140C, H140G, and H140P.
REFERENCES:
patent: 6514729 (2003-02-01), Bentzien
patent: 6800735 (2004-10-01), Whitty et al.
patent: 7381795 (2008-06-01), Carr et al.
Baker Matthew
Carr Francis J.
Carter Graham
Jones Tim
Watkins John
Merck Patent GmbH
Olson & Cepuritis, Ltd.
Rao Manjunath N
Seharaseyon Jegatheesan
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