Modified human thymic stromal lymphopoietin

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.

Reexamination Certificate

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C530S402000

Reexamination Certificate

active

10202699

ABSTRACT:
Modified, furin resistant human TSLP polypeptides and polynucleotides encoding the modified human TSLP polypeptides are provided. Pharmaceutical compositions, B and T cell activation agents, assays and methods of use are also described.

REFERENCES:
patent: 6555520 (2003-04-01), Sims et al.
patent: WO 00/29581 (2000-05-01), None
Mlkayama et al. Proc. Natl. Acad. Sci. USA vol. 90, pp. 10056-10060, 1993.
Voet et al. Biochemistry. John Wiley & Sons, Inc., pp. 126-128 and 228-234.
Levin SD, et al., “Thymic Stromal Lymphopoietin: A Cytokine that Promotes the Development of IgM+B Cells in Vitro and Signals Via a Novel Mechanism,”J Immunology, 162:677-683, 1999.
Pandey A, et al., “Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin,”Nature Immunology, 1(1):59-64, Jul. 2000.
Park LS, et al., “Cloning of the Murine Thymic Stromal Lymphopoietin (TSLP) Receptor: Formation of a Functional Heteromeric Complex Requires Interleukin 7 Receptor,”J Experimental Medicine192(5):659-669, Sep. 2000.
Reche PA, et al., “Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells,”J of Immunology167:336-343,2001.
Sims JE, et al., “Molecular Cloning and Biological Characterizations of a Novel Murine Lymphoid Growth Factor,”J. Experimental Medicine192(5):671-680, Sep. 2000.
Hosaka, et al., “Arg-X-Lys/Arg-Arg Motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway,”J. Biol. Chem.266 (19), 12127-12130, 1991.

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