Modified human pancreatic secretory trypsin inhibitor

Details Modified human pancreatic secretory trypsin inhibitor Modified human pancreatic secretory trypsin inhibitor

1989-07-12

1992-06-16

Lacey, David L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

536 27, 435 692, 4353201, 530845, C07K 710, C12N 1515

Patent

active

051225948

ABSTRACT:
DNA sequences encoding modified varieties of human PSTI possessing excellent stability in terms of decreased susceptibility to decomposition by proteolytic enzymes such as trypsin, as compared with natural human PSTI, as well as the modified varieties of human PSTI obtained by the expression of the DNA sequences.

REFERENCES:
L. J. Greene et al. Methods Enzymol. vol. 45, 1976, pp. 813-825.
T. Yamamoto et al. Biochemical and Biophysical Research Communications, vol. 132, No. 2, Oct. 30, 1985, pp. 605-612.
M. H. Pubols et al. The Journal of Biological Chemistry, vol. 249, No. 7, Apr. 10, 1974, pp. 2235-2242.
G. Feinstein et al. Eur. J. Biochem. 43, 1974 pp. 569-581.

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