Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1990-06-20
1993-08-24
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303873, A61K 3514, C07K 1300
Patent
active
052390616
ABSTRACT:
The present invention relates to modified .beta.-chains of human hemoglobin having an oxygen binding affinity equal to or less than natural human hemoglobin. The modified the .beta.-chain of human hemoglobin of the invention preferably has at least one chloride binding site not present in .beta.-chain of natural human hemoglobin.
REFERENCES:
Bonoventura et al J of Biol Chem 250:6273-6277 1975 (1).
Luisi et al Nature 320:555-556 1986.
Nagai et al PNAS 82:7252-7255 1985 (1).
Nagai et al (2) Nature 329:858-860 1987.
Bonoventura et al J of Biol Chem 243:980-991 1968 (2).
Razynska et al, Biophysical Chemistry, vol. 38, pp. 111-115.
Fronticelli, Biophysical Chemistry, vol. 37, pp. 141-146.
Fronticelli et al, J. Mol. Biol., vol. 202, pp. 343-348 (1988).
Brinigar William
Bucci Enrico
Fronticelli Clara
Nucker Christine M.
Research Corporation Technologies Inc.
Sidberry H. F.
LandOfFree
Modified human hemoglobin, blood substitutes containing the same does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modified human hemoglobin, blood substitutes containing the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified human hemoglobin, blood substitutes containing the same will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-830286