Modified human C3 proteins

Details Modified human C3 proteins Modified human C3 proteins

1997-02-07

1998-12-15

Prouty, Rebecca E.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

530381, 530402, 5303917, 435226, 514 12, 424 9464, C07K 1646, C07K 14745, A61K 3836, A61K 39395

Patent

active

058492976

ABSTRACT:
Narrative complement pathway proteins modified such that the protein is capable of forming a stable C3 convertase. Preferably the modified protein is a modified human C3 protein. DNA sequences encoding such proteins are also provided, together with DNA constructs. Conjugates comprising such proteins and a specific binding moiety, for example an antibody, are also described, as are uses of such proteins and/or conjugates in therapy.

REFERENCES:
patent: 4661347 (1987-04-01), Muller-Eberhard et al.
R.R. Kew et al., "Cigarette Smoke Can Activate the Alternative Pathway of Complement In Vitro by Modifying the Third Component of Complement", J. Clin. Invest. 75: 1000-1007, Mar. 1985.
D.E. Isenman et al., "Nucleophilic Modification of Human Complement Protein C3: Correlation of Conformational Changes With Acquisition of C3b-like Functional Properties", Biochemistry 20: 4458-4467, Jul. 1981
Z. Fishelson et al., "Characterization of the Initial C3 Convertase of the Alternative Pathway of Human Complement", J. Immunol. 132 (3): 1430-1434, Mar. 1984.

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