Modified hookworm neutrophil inhibitors

Details Modified hookworm neutrophil inhibitors Modified hookworm neutrophil inhibitors

1995-05-26

1999-07-06

Fitzgerald, David L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 691, 4351721, C07K 14435, C12N 1501

Patent

active

059199008

ABSTRACT:
Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil Inhibitory Factors which also which inhibit neutrophil activity. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions and recombinant Neutrophil Inhibitory Factors are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.

REFERENCES:
patent: 5242691 (1993-09-01), Beck

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