Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1990-12-21
1993-11-23
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
530351, 530406, 530410, C07K 1506, A61K 3702
Patent
active
052642097
ABSTRACT:
Provided are PEGylated "interleukin-6" derivatives (PEG IL-6) having an extended plasma half-life, as well as enhanced in-vivo IL-6 biological activities.
Methods for producing the modified glycosylated and unglycosylated IL-6 proteins or polypeptides, as well as, for their use in treating hematopoietic disorders and difficiencies, particularly acute thrombocytopenia, are also provided.
REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4766106 (1988-08-01), Katre et al.
patent: 4791192 (1988-12-01), Nakagawa et al.
patent: 4810643 (1989-03-01), Souza
patent: 4847325 (1989-07-01), Shadle et al.
patent: 4904584 (1990-02-01), Shaw
Katre et al., Proc. Natl. Acad. Sci. U.S.A., 84, pp. 1487-1491 (1987).
Koerholz et al., Eur. J. Haematol., 42(5), pp. 417-424 (1982).
Brakenhoff, et al., The Journal of Immunology, 143:1175-1182 (1989).
Castell, et al., Eur. J. Biochem., 177:357-361 (1988).
Goodson, et al., Bio/Technology, 8:343-346 (1990).
Haegeman, et al., Eur. J. Biochem., 159:625-632 (1986).
Hirano, et al., Proc. Nat'l. Acad. Sci. U.S.A., 82:5490-5494 (1985).
Ishibashi, et al., Blood, 74:1241-1244 (1989).
Kishimoti, et al., Ann. Rev. Immunol., 6:485-512 (1988).
Okada, et al., J. Exp. Med., 157:583-590 (1983).
Stocks, et al., Analytical Biochemistry, 154:232-234 (1986).
Inada et al. (1986) Trends in Biotech., Mar., pp. 68-73.
Inoue Hideo
Kadoya Toshihiko
Kakitani Makoto
Mikayama Toshihumi
Furman Keith C.
Kirin-Amgen Inc.
Wax Robert A.
LandOfFree
Modified HIL-6 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modified HIL-6, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified HIL-6 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1846890