Modified hepatitis B virus surface antigen P31 and production th

Details Modified hepatitis B virus surface antigen P31 and production th Modified hepatitis B virus surface antigen P31 and production th

1990-07-03

1992-11-17

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

424 89, 435 693, 4351723, 530363, 530395, C07K 1300, A61K 3929

Patent

active

051644851

ABSTRACT:
A modified protein (i) derived from a hepatitis B virus surface antigen P31 protein and (ii) having hepatitis B virus surface antigen activity and the ability to bind polymerized human serum albumin, wherein the modification comprises rendering at least one trypsin-like protease sensitive site of the hepatitis B virus surface antigen P31 protein insensitive. The modified protein can be used in the production of a vaccine for prevention of hepatitis B virus infections and as an antigen for diagnosis of hepatitis B virus infections.

REFERENCES:
patent: 4775622 (1988-10-01), Hitzeman
patent: 4935235 (1990-06-01), Rutter
Milich et al. (1985) Science 228, 1195-1199.
Machida et al. (1983) Gastorenterology 85, 268-274.

Affiliated with

Also associated with

Rating

Modified hepatitis B virus surface antigen P31 and production th does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modified hepatitis B virus surface antigen P31 and production th, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified hepatitis B virus surface antigen P31 and production th will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1172934