Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1991-11-14
1992-06-02
Schwartz, Richard A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C07K 1300
Patent
active
051187930
ABSTRACT:
A modified heparin cofactor II is disclosed, HCII(Leu.sub.444 .fwdarw.Arg), which has substantially improved inhibitory activity against thrombin compared to native HCII or antithrombin.
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Blinder Morey A.
Derechin Vivianna M.
Tollefsen Douglas M.
LeGuyader John L.
Meyer Scott J.
Passley Paul L.
Schwartz Richard A.
Washington University
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