Modified hemoglobin and its use as a component of an artificial

Details Modified hemoglobin and its use as a component of an artificial Modified hemoglobin and its use as a component of an artificial

1997-07-31

1999-10-05

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530380, 530829, 514 6, 514832, 560 1, 560 8, 560 18, 560 27, 560 34, 560 53, 560 64, A61K 3514, A61K 3816, C07C 6976

Patent

active

059626518

ABSTRACT:
The present invention provides a chemically modified form of hemoglobin that is stabilized and can efficiently bind and release oxygen. In addition the chemically modified hemoglobin may be polymerized to increase its molecular weight and increase its stability so that it will have a longer half life in the circulatory system and may be used as a stable oxygen transport mediator which is useful as the basis of a blood substitute.

REFERENCES:
patent: 5028588 (1991-07-01), Hoffman et al.
patent: 5122539 (1992-06-01), Abraham et al.
patent: 5239061 (1993-08-01), Fronticelli et al.
patent: 5268500 (1993-12-01), Calezari et al.

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