Modified grass pollen antigens

Details Modified grass pollen antigens Modified grass pollen antigens

1979-09-25

1981-03-17

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

260112R, 2601125R, A61K 3936

Patent

active

042567327

ABSTRACT:
Oxidative rearrangement and cleavage of hydroxy aromatic rings of quercitin moiety of Timothy grass pollen antigen or antigenic fragments gives rise to a modified antigen having no antigenic properties but retaining capability of activating T-cells for regulation of immune response.
The invention includes the modified antigens, the method of oxidative cleavage, immunotherapeutic methods for alleviating allergic responses to the Timothy grass pollen antigens and immunotherapeutic compositions therefor.

REFERENCES:
patent: 4140679 (1979-02-01), Malley
patent: 4158705 (1979-06-01), Malley
Malley et al., Immunochemistry, vol. 12, pp. 551-554 (1975).
Girard et al., Chem. Abstracts, vol. 83, 162003u (1975).
Malley et al., J. of Immunology, vol. 99, No. 4 (1967), pp. 825-830.
Malley et al., Chem. Abstracts, vol. 83, 161,957w (1975).
Sanderson et al., Immunology, vol. 20 (1971), pp. 1061-1065.
Axen et al., Nature, vol. 214 (1967), pp. 1302-1304.
Malley et al., J. of Allergy, vol. 43, No. 2 (1969), pp. 59-64.

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