Modified grass pollen antigens

Details Modified grass pollen antigens Modified grass pollen antigens

1978-08-15

1980-07-29

Danison, Walter C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, 424 88, 424 91, 424177, C08H 100, A61K 3936

Patent

active

042150361

ABSTRACT:
Oxidative rearrangement and cleavage of hydroxy aromatic rings of quercitin moiety of Timothy grass pollen antigen or antigen fragments gives rise to a modified antigen having no antigenic properties but retaining capability of activating T-cells for regulation of immune response.
The invention includes the modified antigens, the method of oxidative cleavage, immunotherapeutic methods for alleviating allergic responses to the Timothy grass pollen antigens and immunotherapeutic compositions therefor.

REFERENCES:
Malley et al., Immunochemistry, vol. 12 (6-7), (1975), pp. 551-554.
Girard et al., Chemical Abstracts, vol. 83:162,003u (1975).
Malley et al., J. of Immunology, vol. 99, No. 4 (1967), pp. 825-830.
Malley et al., Chemical Abstracts, vol. 83:161,957w (1975).
Sanderson et al., Immunology, vol. 20 (1971), pp. 1061-1065.
Axen et al., Nature, vol. 214 (1967), pp. 1302-1304.
Malley, et al., J. of Allergy, vol. 43, No. 2 (1969), pp. 59-64.

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