Drug – bio-affecting and body treating compositions – Lymphokine
Reexamination Certificate
2007-04-24
2007-04-24
Mertz, Prema (Department: 1646)
Drug, bio-affecting and body treating compositions
Lymphokine
C530S351000
Reexamination Certificate
active
10469900
ABSTRACT:
The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human granulocyte macrophage colony stimulating factor (GM-CSF) to result in GM-CSF proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.
REFERENCES:
patent: 5349052 (1994-09-01), Delgado et al.
patent: WO 98/52976 (1998-11-01), None
patent: WO 98/59244 (1998-12-01), None
patent: WO 00/34317 (2000-06-01), None
Database EMBL ‘Online!’, Lee, et al.: “GM-CSF” retrieved from EBI Database Accession No. P04141, XP002211037, Abstract, (Nov. 1, 1986).
Database EMBL ‘Online!’, Peters & Rollin: “GM-CSF” retrieved from EBI Database Accession No. Q9GL44, XP002211038, Abstract, (Mar. 1, 2001).
Revoltella, et al., “Natural & Theray-Induced Anti-GM-CFS and Anti-G-CSF . . . ” Leukemia & Lymphoma. (Switzerland) vol. 26, Suppl. 1, pp. 29-34, (Dec. 1997).
H. Mellstedt, “Induction of Anti-Granulocyte-Macrophage Colony-Stimulating Factor Antibodies . . . ” Journal of Interferon Research, vol. 14, No. 4, pp. 179-180 (Feb. 16, 1994).
Sali, et al., “Comparative Protein Modelling by Satisfaction of Spatial Restraints,” J. Mol. Biol., vol. 234, pp. 779-815 (1993).
Altuvia, et al., “Ranking Potential Binding Peptides to MHC Molecules by a Computational Threading Approach,” J. Mol. Biol., vol. 249, No. 1, pp. 244-250 (1995).
Brusic, et al., “MHCPEP, A Database of MHC-Binding Peptides: Update 1997,” Nucleic Acids Research, Vo. 26, No. 1, pp. 368-371 (1998).
Bohm, “Prediction of Binding Constants of Protein Ligands: A Fast Method . . . ”, Journal of Computer-Aided Molecular Design, vol. 4, No. 12, pp. 309-323 (Jul. 1998).
Carr Francis Joseph
Garter Graham
Merck Patent GmbH
Mertz Prema
Olson & Hierl Ltd.
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