Modified glycoprotein hormones having a CTP at the amino terminu

Details Modified glycoprotein hormones having a CTP at the amino terminu Modified glycoprotein hormones having a CTP at the amino terminu

1995-04-10

1998-08-11

Walsh, Stephen

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

530397, 530398, 4241981, 435 697, 930110, C07K 1459, A61K 3824

Patent

active

057924600

ABSTRACT:
"Partial" and "complete" CTP units are used to modify biologically active proteins and peptides to alter their clearance patterns. "Complete" CTP units have the amino acid sequence found at positions 112-118 to position 145 of the .beta.-subunit of human chorionic gonadotropin; "partial" CTP units are missing at least one amino acid in the region of position 118-145 inclusive. Variants of these CTP units contain 1-5 conservative amino acid substitutions which do not destroy activity. Suitable peptides or proteins which may be modified in this manner include various hormones and cytokines.

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