Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1985-08-14
1987-02-17
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530322, A61K 3700, C07K 900
Patent
active
046439870
ABSTRACT:
Novel aracyl glycopeptide derivatives of formula 1 and methods for their preparation from the glycopeptide antibiotics vancomycin, A51568A, A51568B, M43A and M43D, are provided. The new glycopeptide derivatives are useful antibacterial agents.
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Harris et al., "Structure of the Glycopeptide Antibiotic Vancomycin. Evidence for an Asparagine Residue in the Peptide," J. Am. Chem. Soc. 104, 4293-4295 (1982).
Pfeiffer, "Structural Features of Vancomycin," Reviews of Infectious Diseases, vol. 3, Suppl., S205-S209 (Nov.-Dec. 1981).
Perkins, "Specificity of Combination Between Mucopeptide Precursors and Vancomycin or Ristocetin," Biochem. J. 111, 195-205 (1969).
Derwent Abstract No. 84-160164/26 (Eli Lilly and Company) of European Pat. No. 112-184-A (Jun. 27, 1984).
Nagarajan Ramakrishnan
Schabel Amelia A.
Eli Lilly and Company
Harrison Nancy J.
Phillips Delbert R.
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