Modified glucose dehydrogenase

Details Modified glucose dehydrogenase Modified glucose dehydrogenase

1997-09-04

2000-08-15

Achutamurthy, Ponnathapu

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

4353201, 435 14, 4352523, 536 232, C12N 904

Patent

active

061035092

ABSTRACT:
The invention provides a modified pyrrolo-quinoline quinone glucose dehydrogenase (PQQGDH) enzyme protein which is modified to have a substrate specificity to glucose. The modified PQQGDH of the invention exhibits a high substrate specificity compared to the wild type PQQGDH, thus is useful in determining glucose concentration in clinical assays and food analyses. A gene coding for the modified PQQGDH and a glucose sensor comprising the modified PQQGDH are also disclosed.

REFERENCES:
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