Modified glucosaminoglucans having antithrombotic activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514822, 514824, A61K 31725

Patent

active

047177195

ABSTRACT:
Pharmaceutical compositions are described which have antithrombotic activity suitable for the prevention and for the therapy of cardiac infarcts, cerebral infarcts and venous thrombosis. They contain as the active component a fraction of heparin which has been modified by nitrogen desulfatation and succinylation, which fraction contains less than 10% of the N-sulfate groups of the heparin starting material and more than 0.6 succinyl radicals per disaccharide unit. The method of treatment is described.

REFERENCES:
patent: 3118816 (1964-01-01), Cushing
patent: 4351938 (1982-09-01), Barnett
patent: 4385046 (1983-05-01), Milbrath et al.
patent: 4401662 (1983-08-01), Lormeau et al.
Holmer et al., Anticoagulant and Antithrombotic Effects of Heparin and Low Molecular Weight Heparin Fragments in Rabbits, Thrombosis Research 25, pp. 475-485 (1982).
Wolfrom et al., Acetylative Desulfation of Carbohydrate Acid Sulfates, J. Am. Chem. Soc. 72, pp. 2859-2861 (1950).
Hirano et al., Some N-Acyl Derivatives of N-Desulphated Heparin, Carbohydrate Research 59, pp. 285-288 (1977).
Long et al., Effects of Heparin, de-N-sulfated Heparin and de-N-sulfated N-acetylated Heparin on . . . Inhibition of Factors Xa and on . . . Inhibition of Thrombin, Chem. Abs. 98:158403s (1983).
Halfarmaco S.p.A., Modified Glycosaminoglycans with Antilipemic Activity Having No Anticoagulatory Effect and Pharmaceutical Preparations . . . , Chem. Abs. 96:104693b (1981).
Nagasawa et al., Studies of the Influence of N-Substitution in Heparin on its Anticoagulant Activity, Chem. Abstracts 87:62618n (1977).
Thrombosis and Cardiovascular Diseases, Edited by Antonio Strano, Plenum Press, New York and London.
Goodman and Gilman's, "The Pharmacological Basis of Therapeutics" 7th Edition, Macmillan Publishing Co., N.Y., Copyright 1985.
"Platelets in Biology and Pathology" Editor, J. L. Gordon, Cambridge, 1976.
"The Thrombin" vol. 1, Editor, Raymond Machovich, M.D., PhD., D.Sc., 1984.
"The Thrombin" vol. II, Editor, Raymond Machovich, M.D., PhD., D.Sc., 1984.
"Principles of Biochemistry" 6th Edition, by Doctors, White, Handler, Smith, Hill and Lehman, 1973.
"Thrombis Research" vol. 8, pp. 413-416, 1976, Brief Communication.

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