Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Reexamination Certificate
2004-02-06
2010-11-16
Graser, Jennifer E (Department: 1645)
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
C424S192100, C424S193100, C424S201100, C424S234100, C424S235100, C424S246100, C424S248100, C424S196110, C424S184100, C435S173300, C435S243000, C435S245000, C435S252100
Reexamination Certificate
active
07833775
ABSTRACT:
Free-living microbes are provided in which the nucleic acid has been modified so that the microbe is attenuated for proliferation and/or which comprise genetic mutations that attenuate the ability of the microbe to repair its nucleic acid. Methods of using the modified microbes for the loading, activation, and/or maturation of antigen-presenting cells are also provided. Vaccine compositions comprising the modified microbes and/or the antigen-presenting cells and methods of using the vaccines are also provided. The microbes may be further modified to include heterologous antigens, such as tumor antigens or infectious disease antigens, for use as a vaccine against cancer or infectious diseases.
REFERENCES:
patent: 4545987 (1985-10-01), Giles et al.
patent: 4556556 (1985-12-01), Wiesehahn et al.
patent: 4791062 (1988-12-01), Wiesehahn et al.
patent: 5106619 (1992-04-01), Wiesehahn et al.
patent: 5171568 (1992-12-01), Burke et al.
patent: 5180819 (1993-01-01), Cayre
patent: 5399719 (1995-03-01), Wollowitz et al.
patent: 5593823 (1997-01-01), Wollowitz et al.
patent: 5691132 (1997-11-01), Wollowitz et al.
patent: 5830702 (1998-11-01), Portnoy et al.
patent: 5843459 (1998-12-01), Wang et al.
patent: 5877159 (1999-03-01), Powell et al.
patent: 6004815 (1999-12-01), Portnoy et al.
patent: 6051237 (2000-04-01), Paterson
patent: 6093725 (2000-07-01), Cook et al.
patent: 6099848 (2000-08-01), Frankel et al.
patent: 6133460 (2000-10-01), Wollowitz et al.
patent: 6143490 (2000-11-01), Cook et al.
patent: 6143551 (2000-11-01), Goebel
patent: 6150170 (2000-11-01), Powell et al.
patent: 6150424 (2000-11-01), Breitenbach et al.
patent: 6153430 (2000-11-01), Pastan et al.
patent: 6171777 (2001-01-01), Cook et al.
patent: 6177441 (2001-01-01), Cook et al.
patent: 6270952 (2001-08-01), Cook et al.
patent: 6287556 (2001-09-01), Portnoy et al.
patent: 6403080 (2002-06-01), Segal
patent: 6410219 (2002-06-01), Cook et al.
patent: 6440735 (2002-08-01), Gaeta
patent: 6455286 (2002-09-01), Wollowitz et al.
patent: 6497876 (2002-12-01), Maraskovsky et al.
patent: 6514987 (2003-02-01), Cook et al.
patent: 6565852 (2003-05-01), Paterson
patent: 6605286 (2003-08-01), Steidler et al.
patent: 6682729 (2004-01-01), Powell et al.
patent: 6709810 (2004-03-01), Cook et al.
patent: 2001/0023072 (2001-09-01), Crawford et al.
patent: 2002/0025323 (2002-02-01), Paterson et al.
patent: 2002/0028206 (2002-03-01), Paterson
patent: 2002/0028432 (2002-03-01), Cook et al.
patent: 2002/0039588 (2002-04-01), Collier et al.
patent: 2002/0045587 (2002-04-01), Goebel
patent: 2002/0136738 (2002-09-01), Agrewala et al.
patent: 2002/0141977 (2002-10-01), Collins et al.
patent: 2002/0150588 (2002-10-01), Allison et al.
patent: 2002/0155108 (2002-10-01), Barbera-Guillem
patent: 2002/0182581 (2002-12-01), Cook et al.
patent: 2002/0192193 (2002-12-01), Chokri et al.
patent: 2003/0077263 (2003-04-01), Maraskovsky et al.
patent: 2003/0082510 (2003-05-01), Wollowitz et al.
patent: 2003/0092177 (2003-05-01), Belardelli et al.
patent: 2003/0113704 (2003-06-01), Stassinopoulos et al.
patent: 2003/0119187 (2003-06-01), De Santis
patent: 2003/0190682 (2003-10-01), Law et al.
patent: 2003/0202985 (2003-10-01), Paterson
patent: 2003/0203472 (2003-10-01), Portnoy et al.
patent: 2004/0009194 (2004-01-01), Andrieu et al.
patent: 2004/0013690 (2004-01-01), Portnoy et al.
patent: 2004/0022761 (2004-02-01), Banchereau et al.
patent: 2004/0029897 (2004-02-01), Cook et al.
patent: 2004/0037807 (2004-02-01), Goldman
patent: 2004/0038398 (2004-02-01), Crawford et al.
patent: 2004/0180321 (2004-09-01), Cook et al.
patent: 2004/0228877 (2004-11-01), Dubensky, Jr. et al.
patent: 2005/0175630 (2005-08-01), Raz et al.
patent: 2005/0249748 (2005-11-01), Dubensky, Jr. et al.
patent: 2005/0281783 (2005-12-01), Kinch et al.
patent: 2007/0031457 (2007-02-01), Dubensky, Jr. et al.
patent: 2 686 896 (1993-08-01), None
patent: 2 686 896 (1993-08-01), None
patent: WO 89/04669 (1989-06-01), None
patent: WO 89/09616 (1989-10-01), None
patent: WO 90/11089 (1990-10-01), None
patent: WO 90/14436 (1990-11-01), None
patent: WO 93/15212 (1993-08-01), None
patent: WO 96/14087 (1996-05-01), None
patent: WO 96/34631 (1996-11-01), None
patent: WO 96/39818 (1996-12-01), None
patent: WO-97/22349 (1997-06-01), None
patent: WO 98/02523 (1998-01-01), None
patent: WO-98/09616 (1998-03-01), None
patent: WO 98/30545 (1998-07-01), None
patent: WO 98/31786 (1998-07-01), None
patent: WO-98/33386 (1998-08-01), None
patent: WO-99/03976 (1999-01-01), None
patent: WO-99/03976 (1999-01-01), None
patent: WO 99/25376 (1999-05-01), None
patent: WO 99/26476 (1999-06-01), None
patent: WO 99/29884 (1999-06-01), None
patent: WO-99/29884 (1999-06-01), None
patent: WO 99/34007 (1999-07-01), None
patent: WO 99/47646 (1999-09-01), None
patent: WO-00/09156 (2000-02-01), None
patent: WO 99/34839 (2000-07-01), None
patent: WO 01/08701 (2001-02-01), None
patent: WO 01/24637 (2001-04-01), None
patent: WO 01/27295 (2001-04-01), None
patent: WO-01/27295 (2001-04-01), None
patent: WO 01/72329 (2001-10-01), None
patent: WO-01/77358 (2001-10-01), None
patent: WO-01/77358 (2001-10-01), None
patent: WO-02/33109 (2002-04-01), None
patent: WO-02/33109 (2002-04-01), None
patent: WO-02/40046 (2002-05-01), None
patent: WO 02/50262 (2002-06-01), None
patent: WO 02/062298 (2002-08-01), None
patent: WO 02/20982 (2002-10-01), None
patent: WO 02/077249 (2002-10-01), None
patent: WO-02/083879 (2002-10-01), None
patent: WO-02/083879 (2002-10-01), None
patent: WO 02/097044 (2002-12-01), None
patent: WO 03/061379 (2003-07-01), None
patent: WO-03/083056 (2003-10-01), None
patent: WO-03/083056 (2003-10-01), None
patent: WO 03/092600 (2003-11-01), None
patent: WO 03/102168 (2003-12-01), None
patent: WO 2004/006837 (2004-01-01), None
patent: WO-2004/011492 (2004-02-01), None
patent: WO 2004/084936 (2004-10-01), None
patent: WO 2004/110481 (2004-12-01), None
patent: WO-2005/009463 (2005-02-01), None
patent: WO-2005/009463 (2005-02-01), None
patent: WO-2005/037233 (2005-04-01), None
patent: WO-2005/037233 (2005-04-01), None
patent: WO-2005/067460 (2005-07-01), None
patent: WO-2005/067460 (2005-07-01), None
patent: WO-2005/071088 (2005-08-01), None
patent: WO-2005/071088 (2005-08-01), None
patent: WO-2005/092372 (2005-10-01), None
Bowie et al., “Deciphering tl˜e Message in Protein Sequences: Tolerance to Amino Acid Substitutions,” Science, Colume 247, pp. 1306-1310 (1990).
Anonymous (Feb. 4, 2003). “Cerus Corporation Starts Vaccine Trial for Epstein-Barr Virus,”Press Release, Cerus Corporation, located at <http://www.cerus.com/pages/PR/2003/PRO20403.html> last visited on Nov. 8, 2004, two pages.
Henderson, R.A. et al. (Jul. 15, 1997). “Activation of Human Dendritic Cells Following Infection withMycobacterium tuberculosis,”The Journal of Immunology159(2):635-643.
Invitation to Pay Additional Fees mailed Jan. 5, 2005, for PCT Application No. PCT/US2004/023881 filed Jul. 23, 2004, seven pages.
Invitation to Pay Additional Fees mailed Jan. 18, 2005, for PCT Application No. PCT/US2004/003671 filed Feb. 6, 2004, seven pages.
Maru, G. B. et al. (1987). “Formation and Persistence of Isoniazid-DNA Adducts in Mouse Tissues,”BIOSIS Database, Biosciences Information Service, Database Accession No. PREV198783117667, Abstract, one page.
Maru, G. B. et al. (1987). “Formation and Persistence of Isoniazid-DNA Adducts in Mouse Tissues,”Human Toxicology6(2):153-158.
Rescigno, M. et al. (Mar. 2001). “Dendritic Cells, Loaded with Recombinant Bacteria Expressing Tumor Antigens, Induce a Protective Tumor-Specific Response,”Clinical Cancer Research7(Suppl.):865s-870s.
Rescigno, M. et al. (Mar. 2001). “Dendritic Cells, Loaded with Recombinant Bacteria Expressing Tumor Antigens, Induce a Protective Tumor-Specific Response,”Medline Database, U.S. National Library of Medicine(NLM), Database Accession No. NLM11300484. Abstract, one page.
Sashinami, H. et al. (Jan. 2003). “Effective Induction of Acquired Resistance toListeria monocytogenesby Immuni
Brockstedt Dirk G.
Cook David N.
Dubensky, Jr. Thomas W.
Hearst John E.
Aduro BioTech
Biotechnology Law Group
Graser Jennifer E
Whittaker Michael A.
LandOfFree
Modified free-living microbes, vaccine compositions and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modified free-living microbes, vaccine compositions and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified free-living microbes, vaccine compositions and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4193223