Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Reexamination Certificate
2007-11-13
2010-02-16
Raghu, Ganapathirama (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
C435S200000, C435S014000, C435S069100, C435S091100, C435S320100, C435S252300, C435S325000, C536S023200, C536S023100
Reexamination Certificate
active
07662600
ABSTRACT:
An object of the present invention is to provide a more practically advantageous enzyme usable as a reagent for measuring blood glucose than the known enzymes used as blood glucose sensors.A modified flavin adenine dinucleotide dependent glucose dehydrogenase (FADGDH) with more improved heat stability than FADGDH derived from wild-type FADGDH, the modified FADGDH being derived from preferably a eukaryote, more preferably a filamentous fungus, and furthermore preferably anAspergillusfungus, and, for example, those having a primary structure with at least one amino acid substituted, deleted, inserted or added to FADGDH having an amino acid sequence represented by SEQ ID Nos. 2 or 46 in the sequence table.
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Bak et al.,Biochimica et Biophysica Acta, 139(2): 277-293 (1967).
Kawaminami Hiroshi
Kitabayashi Masao
Nishiya Yoshiaki
Tsuji Yuji
Leydig , Voit & Mayer, Ltd.
Raghu Ganapathirama
Toyo Boseki Kabushiki Kaisha
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