Modified factor VIII

Details Modified factor VIII Modified factor VIII

1989-01-18

1990-11-13

Kight, III, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

536112, 525 541, 530322, 530362, 530363, 530395, A61K 3514, C08H 100, C08L 8900, C08B 3702

Patent

active

049703005

ABSTRACT:
Disclosed are conjugates of a protein having antihemophilic factor (Factor VIII) activity linked to nonantigenic ligands. The conjugates have longer half life than the unconjugated protein but maintain substantial Factor VIII activity.

REFERENCES:
patent: 4229537 (1980-10-01), Hodgins et al.
patent: 4446316 (1984-05-01), Chazov et al.
patent: 4496689 (1985-01-01), Mitra
patent: 4698387 (1987-10-01), Schmidt et al.
Finlay, T. H. et al., Anal. Biochem., 87:77, 1978.
Beauchamp, C. O. et al., Anal. Biochem., 131:25-33, 1983.
Bonneaux, F. et al., Experimentia, 37:884-886, 1981.
Hoyer, L. W., Blood, 58:1-13, 1981.
Over et al., J. Clin. Invest., 62:223-234, 1978.
Strauss, H. S. , N. Engl. J. Med., 281:866, 1969.
Abuchowski, A. et al., J. Biol. Chem., 252:3578-3581, 1977.
Wood, W. I. et al., Nature, 312:330-337, 1984.
Vehar, G. A. et al., Nature, 312:337-342.
Toole, J. J. et al., Nature, 312:342-347, 1984.
Rotblatt, T. et al., Thromb. Haemost., 50:108, 1983.
Weiss, H. J. et al., Science, 182:1149-1151, 1973.
Fulcher, C. A. et al., J. Clin. Invest., 76:117-124, 1985.
Eaton et al., Biochemistry, 25:505-512, 1986.
Gitschier, J. et al., Nature, 312:326-330, 1984.

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