Modified factor VII

Details Modified factor VII Modified factor VII

1994-10-24

1998-10-06

Jacobson, Dian C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435212, 435226, 435325, C12N 510, C12N 964, C12N 1555, C12N 1557

Patent

active

058177884

ABSTRACT:
The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagulation cascade. The modifications render Factor VIIa substantially unable to activate plasma Factors X or IX. Pharmaceutical compositions of the modified Factor VII are used to treat a variety of coagulation-related disorders.

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