Modified dendritic cells and use therefor

Details Modified dendritic cells and use therefor Modified dendritic cells and use therefor

2005-08-16

2005-08-16

Wehbé, Anne M. (Department: 1632)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093300, C424S093710, C424S093720, C424S093200, C424S093100, C435S325000, C435S320100, C435S455000, C514S04400A

Reexamination Certificate

active

06929792

ABSTRACT:
The invention provides isolated dendritic cells genetically modified to express a selectin polypeptide, optionally treated with activated platelets or membrane microparticles thereof. The invention also provides isolated platelet modified dendritic cells. Methods for delivering the modified dendritic cells to peripheral lymph nodes and methods for using the modified dendritic cells to stimulate immune responses also are provided. Vaccine compositions containing the modified dendritic cells also are provided.

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