Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Reexamination Certificate
2005-05-10
2005-05-10
Ulm, John (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
C530S350000, C530S418000, C514S002600
Reexamination Certificate
active
06891025
ABSTRACT:
A modified extracellular domain of a cytokine receptor is capable of being crystallized without being complexed to a ligand molecule. The receptor preferably is a homo- or heterodemeric receptor having at least one molecule segment which contributes to a disorder structure deleted. A preferred receptor is human growth hormone receptor (hGHR).
REFERENCES:
Muller, Y.A. et al. J. Mol.Biol. (1996) 256, 144-159.*
Kaczmarski et al Abstract, “The Cytokine Receptor Superfamily,”Blood Rev., 5 (3):193-203 (1991).
Sundström et al,Journal of Biological Chemistry,271(50):32197-32203 (Dec. 13, 1996).
DeVos et al,Science, 255:306-312 (1992).
WPI Abstract of JP 6172394 dated Jun. 21, 1994.
Norstedt Gunnar
Sundström Michael
Chernyshev Olga N.
Dinsmore & Shohl LLP
Pharmacia AB
Ulm John
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