Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-07
2000-01-04
Kemmerer, Elizabeth
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 234, 536 235, 514 12, 530350, C12N 1512, C12N 1562, C07K 1446
Patent
active
060108738
ABSTRACT:
Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which effect the binding of these proteins, identified as amino acids 35, 64-65, 92-94 (C4b) and the sequence S-T-K-P-(P-I-C)-Q (amino acids at positions 54-61 of SEQ ID NO. 13) (C3b) in the CR1 protein can be transferred to corresponding regions of CR1 or of additional members of the RCA family. Analogs can also be designed by substituting amino acids which affect the binding of these proteins into homologous regions of noncorresponding SCRs of CR1 or other family members.
REFERENCES:
patent: 4935233 (1990-06-01), Bell et al.
Wong et al. Proposed structure of the F' allotype of human CR1. Loss of a C3b binding site may be associated with altered function. J. Immunol. (Jan. 1991), 146(2), 656-62, Jan. 1991.
Hourcade et al. Identification of an alternative polyadenylation site in the human C3b/C4b receptor (complement receptor type 1) transcriptional unit and prediction of a secreted form of complement receptor type 1. J Exp Med, (Oct 1, 1988) 168 (4) 1255-7.
Hourcade et al. The regulators of complement activation (RCA) gene cluster. Adv Immunol, (1989) 45 381-416.
Weisman et al. Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis. Science, (Jul. 13, 1990) 249 (4965) 146-51.
Atkinson John P.
Hourcade Dennis
Krych Malgorzata
Kemmerer Elizabeth
Romeo David S.
Washington University
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