Modified complement system regulators

Details Modified complement system regulators Modified complement system regulators

1994-03-18

1996-08-13

Walsh, Stephen G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, A61K 3836, C07K 14705, C07K 14745

Patent

active

055456197

ABSTRACT:
Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which effect the binding of these proteins, identified as amino acids 35, 64-65, 92-94 (C4b) and the sequence S-T-K-P-(P-I-C)-Q (SEQ ID NO:1) (C3b) in the CR1 protein can be transferred to corresponding regions of CR1 or of additional members of the RCA family. Analogs can also be designed by substituting amino acids which affect the binding of these proteins into homologous regions of noncorresponding SCRs of CR1 or other family members.

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