Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1994-01-03
1999-02-09
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530350, 514 12, 435 691, A61K 3514
Patent
active
058696156
ABSTRACT:
Variant complement proteins that are modified in their complement-mediated activity are provided, along with methods for their preparation, and their potential uses. The modifications comprise amino acid substitutions in regions of the complement proteins that contain certain motifs also present in homologous proteins. The amino acid substitutions and their effect on the complement activity of the modified protein are also provided.
REFERENCES:
Mole J.E. et al. (1984) Complete Primary Structure for the Zymogen of Human Complement Factor B.J. Biol. Chem. 259, pp. 3407-3412, 1984.
Krych M. et al. (1991) Sites Within the Complement C3b/C4b Receptor Important for the Specificity of Ligand Binding. Proc. Natl. Acad. Sci. USA. 88, pp. 4353-4357, 1991.
Almquist et al., "Synthesis and Biological Activity of a Ketomethylene Analogue of a Tripeptide Inhibitor of Angiotensin Converting Enzyme" J. Med. Chem. 23:1392-1398 (1980).
Beaucage et al., "Deoxynucleoside Phosphoramidites --A New Class of Key Intermediates for Deoxypolynucleotide Synthesis" Tetr. Lett. 22(20):1859-1862 (1981).
Chaiken, "Semisynthetic Peptides and Proteins" CRC Crit. Rev. Biochem. 11:255-301 (1981).
Cole et al., "Identification of an additional class of C3-binding membrane proteins of human peripheral blood leukocytes and cell lines" proc. Natl. Acad. Sci. USA 82:859-863 (1985).
Columbatti et al., "The Superfamily of Proteins With von Willebrand Factor Type A-Like Domains: One Theme Common to Components of Extracellular Matrix, Hemostasis, Cellular Adhesion, and Defense Mechanisms"Blood 77(11):2305-2315 (1991).
Dykman et al., "Polymorphism of human erythrocyte C3b/C4b receptor"Prod. Natl. Acad. Sci. USA 80(6):1698-1702 (1983a).
Dykman et al., "Structural Heterogeneity of the C3b/C4b Receptor (CR1) on Human Peripheral Blood Cells" J. Exp. Med. 157(6):2160-2165 (1983b).
Ebenbichler et al., "Human Immunodeficiency Virus Type 1 Activates the Classical Pathway of Complement by Direct C1 Binding through Specific Sites in the Transmembrane Glycoprotein gp41" J. Exp. Med. 174:1417-1424 (1991).
Evans et al., "Design of Nonpeptidal Ligands for a Peptide Receptor: Cholecystokinin Antogonists" J. Med. Chem. 30:1229-1239 (1987).
Fauchere, "Elements for the Rational Design of Peptide Drugs" Adv. Drug Res. 15:29-69 (1986).
Felgner et al., "Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure" Proc. Natl. Acad. Sci. USA 84:7413-7417 (1987).
Green et al., "A versatile in vivo and in vitro eukaryotic expression vector for protein engineering" Nucl. Acids Res.16(1):369 (1988).
Hann, "On the Double Bond Isostere of the Peptide Bond: Preparation of an Enkephalin Analogue" J. Chem. Soc. Perkin Trans. I 307-314 (1982).
Holladay et al., "Synthesis of Hydroxyethylene and Ketomethylene Dipeptide Isosteres" Tetrahedron Lett. 2441):4401-4404 (1983).
Horiuchi et al., "cDNA Cloning and Expression of Human Complement Component C2" J. Immunol. 142(6):2105-2111 (1989).
Horiuchi et al., "Site-Directed Mutagenesis of the Region Around Cys-241 of Complement Component C2: Evidence for a C4b Binding Site" J. Immunol. 147(2):584-589 (1991).
Horiuchi et al., "Human Complement Factor B: cDNA Cloning, Nucleotide Sequencing, Phenotypic Conversion by Site-Directed Mutagenesis and Expression" Molecular Immunology 30(17):1587-1592 (1993).
Hourcade et al., "The Regulators of Complement Activation (RCA) Gene Cluster" Adv. Immunology 45:381-416 (1989).
Hruby, "Conformational Restrictions of Biologically Active Peptides Via Amino Acid Side Chain Groups" Life Sci. 31:189-199 (1982).
Hudson et al., "Methionine Enkephalin and Isosteric Analogues" Int. J. Pept. Prot. Res. 14:177-185 (1979).
Jennings-White et al., "Synthesis of Ketomethylene Analogs of Dipeptides" Tetrahedron Lett. 23(25):2533-2534 (1982).
Kaiser et al., "Peptide and Protein Synthesis by Segment Synthesis-Condensation" Science 243:187-191 (1989).
Kent, "Chemical Synthesis of Peptides and Proteins" Ann. Rev. Biochem. 57:957-989 (1988).
Kim et al., "Investigation of Structural Correlates of Factor D Function by Site-Directed Mutagenesis" Mol. Immunol. 30:23 (1993).
Krych et al., "Sites within the complement C3b/C4b receptor important for the specificity of ligand binding" Proc. Natl. Acad. Sci. USA 88:4353-4357 (1991).
Krych et al., "Analysis of the Functional Domains of Complement Receptor Type 1 C3b/C4b Receptor; CD35) by Substitution Mutagenesis" J. Biol. Chem. 269(18):13273-13278 (1994).
Laemmli, "Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4" Nature 227:680-685 (1970).
Luo et al., "Recombinant Human Complement Subcomponent C1s Lacking .beta.-Hydroxyasparagine, Sialic Acid, and One of Its Two Carbohydrate Chains Still Reassembles with C1q and C1r To Form a Functional C1 Complex" Biochem. 31:4254-4262 (1992).
Matteucci et al., "Synthesis of Deoxyoligonucleotides on a Polymer Support" J. Am. Chem. Soc. 103:3185-3191 (1981).
Mejia et al., "Human Factor B: Complete cDNA sequence of the BF*S allele" Hum. Immunol. 39:49-53 (1994).
Merrifield, "Solid Phase Synthesis" Science 232:341-347 (1986).
Merrifield, "The Total Synthesis of an Enzyme with Ribonuclease A Activity" J. Am. Chem. Soc. 91:501-502 (1969).
Michishita et al., "A Novel Divalent Cation-Binding Site in the A Domain of the .beta.2 Integrin CR3 (CD11b/CD18) is Essential for Ligand Binding" Cell 72:857-867 (1993).
Mole et al., "Complete Primary Structure for the Zymogen of Human Complement Factor B" J. Biol. Chem. 259(6):3407-3412 (1984).
Morley, "Modulation of the action of regulatory peptides by structural modification" Trends Pharm. Sci. 463-468 (1980).
Mueckler et al., "The Human Glucose Transporter Can Insert Posttranslationally into Microsomes" Cell 44:629-637 (1986).
Mu ller-Eberhard, "Complement: Chemistry and Pathways" Inflammation: Basic Principles and Clinical Correlates, Chapter 3:33-61 (Raven Press, Ltd., New York, 2nd Ed.) (1992).
Mulligan et al., "Protective Effects of Soluble CR1 in Complement-and Neutrophil-Mediated Tissue Injury" J. Immunology 148:1479-1485 (1992).
Needleman et al., "A General Method Applicable to the Search for Similarities in the Amino Acid Sequence of Two Proteins" J. Mol. Biol. 48:443-453 (1970).
Pearson et al., "Improved tools for biological sequence comparison" Proc. Natl. Acad. Sci. (U.S.A.) 85:2444-2448 (1988).
Perkins et al., "A Study of the Structure of Human Complement Component Factor H by Fourier Transform Infrared Spectroscopy and Secondary Structure Averaging Methods" Biochem. 2711):4004-4012 (1988).
Perkins et al., "The Secondary Structure of the von Willebrand Factor Type A Domain in Factor B of Human Complement by Fourier Transform Infrared Spectroscopy: Its Occurrence in Collagen Types VI, VII,XII and XIV, the Integrins and Other Proteins by Averaged Structure Predictions" J. Mol. Biol. 238:104-119 (1994).
Pruitt et al., "The Effect of Soluble Complement Receptor Type 1 on Hyperacute Xenograft Rejection" Transplantation 52(5):868-873 (1991).
Reid et al., "Structure-function relationships of the complement components" Immuonl. Today 10(6):177-180 (1989).
Remington's Pharmaceutical Sciences, vol. 1, 19th Ed. (Mack Publishing Co., Easton, Pennsylvania, 1995) Table of Contents, emphasis on Chapter 38 "Stability of Pharamaceutical Products", Chapter 56 Respiratory Drugs, and Chapter 95 Aerosols.
Rizo et al., "Constrained Peptides: Models of Bioactive Peptides and Protein Substructures" Ann. Rev. Biochem. 61:387-418 (1992).
Schwaeble et al., "Human Complement Factor B: Functional Properties of a Recombinant Zymogen of the Alternative Activation Pathway Convertase" Immunobiol. 188:221-232 (1993).
Schwaeble et al.,"Human Complement Factor B: Functional Properties of a Recombinant Zymogen of the Alternative Activation Pathway Convertase" EMBL/GenBank/DDBJ Database. Accession No. S67310 1994) (cited in divisional case U.S.S.N. 08/687,706, copy not received with office action, should be the same as disclosed in 1993 paper).
Smith et al., Adv. Appl. Math. 2:482 (1981).
Smith et al., "Ultrastructure of Cobra Venom Factor-dependent C3/C5 Convertase a
Hourcade Dennis E.
Oglesby Teresa J.
Longton Enrique D.
Washington University
Wax Robert A.
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