Modified chlorhexidine adduct

Details Modified chlorhexidine adduct Modified chlorhexidine adduct

1993-07-07

1995-02-28

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Dentifrices

Fluorine or fluorine compound containing

424 54, 514635, 564735, C07C27918, A61K 718, A61K 722, A61K 31155

Patent

active

053935160

ABSTRACT:
A chlorhexidine adduct is described, which comprises one molecule of chlorhexidine with three molecules of hydrogen fluoride and one molecule of hydrogen tin trifluoride. The adduct displays a high antibacterial effectiveness against Streptococcus mutans even in very low concentrations.

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Chemical Abstracts, vol. 105, No. 17, Oct. 27, 1986.
Abstract of German application DE-1-2 158 150 (May 1972).
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Gjermo, "Chlorhexidine and Related Compounds", J. Dent, Res. 68 (1989), pp. 1602-1608.
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Flotra et al., "Side Effects of Chlorhexidine Mouth Washes", Scand. J. Dent. Res. 1971, 79 pp. 119-125.
Ellingsen et al., "The Effects of Stannous and Stannic Ions on the Formation and Acidogenicity of Dental Plaque in vivo", Acta Odontol. Scand. 38, (1980) pp. 219-222.
Tinanoff et al., "The Effect of NaF and SnF.sub.2 Mouthrinses on Bacterial Colonization of Tooth Enamel: TEM and SEM Studies", Caries Res. 10 (1976) pp. 415-426.
Ellingsen, "Scanning Electron Microscope and Electron Microprobe Study of Reactions of Stannous Fluoride and Stannous Chloride With Dental Enamel", J. Dent. Res. 94, (1986), pp. 299-305.
Ellingsen et al., "Treatment of Dentin With Stannous Fluoride - SEM and Electron Microprobe Study", Scand, J. Dent, Res. 95 (1987) pp. 281-286.

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