Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-12-13
2005-12-13
Seaman, D. Margaret (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
06974873
ABSTRACT:
Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
REFERENCES:
patent: 3864644 (1975-02-01), Lincoln et al.
patent: 4011086 (1977-03-01), Simson
patent: 4711955 (1987-12-01), Ward et al.
patent: 4981977 (1991-01-01), Southwick et al.
patent: 4997928 (1991-03-01), Hobbs
patent: 5047519 (1991-09-01), Hobbs et al.
patent: 5049673 (1991-09-01), Tsien et al.
patent: 5171534 (1992-12-01), Smith et al.
patent: 5196306 (1993-03-01), Bobrow et al.
patent: 5208148 (1993-05-01), Haugland et al.
patent: 5268486 (1993-12-01), Waggoner et al.
patent: 5332666 (1994-07-01), Prober et al.
patent: 5405975 (1995-04-01), Kuhn et al.
patent: 5436134 (1995-07-01), Haugland et al.
patent: 5453505 (1995-09-01), Lee et al.
patent: 5453517 (1995-09-01), Kuhn et al.
patent: 5486616 (1996-01-01), Waggoner et al.
patent: 5496700 (1996-03-01), Ligler et al.
patent: 5516911 (1996-05-01), London et al.
patent: 5539082 (1996-07-01), Nielsen et al.
patent: 5556959 (1996-09-01), Brush et al.
patent: 5567588 (1996-10-01), Gold et al.
patent: 5569587 (1996-10-01), Waggoner
patent: 5569766 (1996-10-01), Waggoner et al.
patent: 5580990 (1996-12-01), Van den Berg et al.
patent: 5583001 (1996-12-01), Bobrow et al.
patent: 5627027 (1997-05-01), Waggoner
patent: 5639874 (1997-06-01), Middendorf et al.
patent: 5648270 (1997-07-01), Kuhn et al.
patent: 5659025 (1997-08-01), Engels et al.
patent: 5668268 (1997-09-01), Tang et al.
patent: 5679785 (1997-10-01), Engels et al.
patent: 5684142 (1997-11-01), Mishra et al.
patent: 5714327 (1998-02-01), Houthoff et al.
patent: 5714386 (1998-02-01), Roederer
patent: 5731158 (1998-03-01), Bobrow et al.
patent: 5767287 (1998-06-01), Bobrow et al.
patent: 5808044 (1998-09-01), Brush et al.
patent: 5831098 (1998-11-01), Ollmann
patent: 5877310 (1999-03-01), Reddington et al.
patent: 5985566 (1999-11-01), Houthoff et al.
patent: 5986086 (1999-11-01), Brush et al.
patent: 6002003 (1999-12-01), Shen et al.
patent: 6004536 (1999-12-01), Leung et al.
patent: 6008373 (1999-12-01), Waggoner et al.
patent: 6027709 (2000-02-01), Little et al.
patent: 6043025 (2000-03-01), Minden et al.
patent: 6048982 (2000-04-01), Waggoner
patent: 6083485 (2000-07-01), Licha et al.
patent: 6086737 (2000-07-01), Patonay et al.
patent: 6114350 (2000-09-01), Randall et al.
patent: 6127134 (2000-10-01), Minden et al.
patent: 6130094 (2000-10-01), Waggoner et al.
patent: 6133445 (2000-10-01), Waggoner et al.
patent: 6150510 (2000-11-01), Seela et al.
patent: 6197956 (2001-03-01), Randall et al.
patent: 6204389 (2001-03-01), Randall et al.
patent: 6224644 (2001-05-01), Randall et al.
patent: 6258340 (2001-07-01), Licha et al.
patent: 2003/0138791 (2003-07-01), Haalck et al.
patent: 100 46 215 A 1 (2002-04-01), None
patent: 1 065 250 (2001-01-01), None
patent: 870753 (1958-06-01), None
patent: WO 93/04357 (1993-03-01), None
patent: WO 94/05688 (1994-03-01), None
patent: WO 97/40104 (1997-10-01), None
patent: WO 99/51702 (1999-10-01), None
patent: WO 99/64519 (1999-12-01), None
patent: WO 2000/31534 (2000-06-01), None
patent: WO 01/02374 (2001-01-01), None
patent: WO 01/21624 (2001-03-01), None
patent: WO 02/26980 (2002-04-01), None
Martini, CA 125:233368, abstract of Chemical Physics Letters, vol. 258(1,2), pp 180-186, 1996.
Hollars, christopher, The Journal of Physical chemistry B, vol. 101, Nyumber 33, p. 6313-6317, 1997.
U.S. Appl. No. 60/258,266, filed 2000, Martin et al.
U.S. Appl. No. 09/557,275, filed 2000, Haugland et al.
Ozmen et al. Tet. Lett. 41, 9185-88 (2000).
Gruber et al. Bioconjugate Chem. 11, 696 (2000).
Mishra, et al. Chem. Rev. 100, 1973 (2000).
Atamna et al. Proc. Natl. Acad. Sci. U S A 97, 686-691 (2000).
Raju et al. Am. J. Physiol. 256, C540 (1989).
McMahan SA, Burgess RR. Anal Biochem 236, 101-106 (1996).
Piatek et al., Nature Biotechnology 16, 49 (1998).
R. Haugland, Molecular Probes Handbook of Fluorescent Probes and Research Chemicals, Chapters 1-3 (1996).
Brinkley, Bioconjugate Chem. 3, 2 (1992).
Brooker, et al., J. Am. Chem. Soc., 64, 199 (1942).
Heravi, et al., Indian J. Chem. 36B, 1025 (1997).
Mujumdar et al. Bioconjugate Chemistry 4, 105-111(1993).
Mujumdar et al. Bioconjugate Chem. 7, 356-362 (1996).
M.Y. Chu-Moyer and Berger J. Org. Chem. 60, 5721-5725 (1995).
Smith, et al. Sulfur Letters, 17, 197-216 (1994).
Ficken et al., J Chem. Soc. 3202 (1959).
Bannwarth et al. Tet. Lett. 1157-1160 (1991).
Licha et al. Tet. Lett., 1711-1715 (2000).
Amlaiky et al., Febs Lett 176, 436 (1984).
Haugland et al., Meth. Mol. Biol. 45, 205 (1995).
Haugland, Meth. Mol. Biol. 45, 223 (1995).
Haugland, Meth. Mol. Biol. 45, 235 (1995).
Haugland, Current Protocols in Cell Biology 16.5.1-16.5.22 (2000).
Estep & Miller Anal Biochem 157, 100-105 (1986).
Kendall et al. J. Biol. Chem. 257, 13892 (1982).
Szoka et al. Proc. Natl. Acad. Sci. USA 75, 4194 (1978).
Szoka, Jr. et al. Ann. Rev. Biophys. Bioeng. 9, 467 (1980).
Turner, J. Org. Chem. 48, 3401 (1983).
Couture et al. Heterocyclic Chem. 24, 1765 (1987).
Petric et al. J. Heterocyclic Chem. 14, 1045 (1977).
Saikachi et a. Chem. & Pharm. Bull. 9, 941 (1961).
Barlin Aust. J. Chem. 36, 983 (1983).
Foye et al. J. Pharm. Sci. 64, 1371 (1975).
Khanna et al. J. Org. Chem. 60, 960 (1995).
Ficken et al., J Chem. Soc. 584 (1961).
Barlin, G.B., et al. 1984. “Purine Analogues as Amplifiers of Phleomycin. IX* Some 2- and 6-Substituted Thiazolo[4,5-b]pyrazines, 2-Substituted Thiazolo[4,5-c]- and Thiazolo[5,4-b]-pyridines and Related Compounds.”Aust. J. Chem.37: 1729-37.
Cheung Ching-Ying
Leung Wai-Yee
Yue Stephen
Anderson Koren
Molecular Probes, Inc.
Seaman D. Margaret
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