Modified bovine adenovirus having altered tropism

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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C424S093200, C424S199100, C424S233100, C435S069100, C435S173300, C435S235100, C536S023720

Reexamination Certificate

active

06849446

ABSTRACT:
The present invention provides modified bovine adenoviruses comprising a modification in a capsid protein wherein said protein is associated with adenovirus tropism and wherein said modification is associated with altered tropism. The present invention provides adenovirus vectors and host cells comprising such vectors. The present invention also provides methods of making and using such adenoviruses.

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