Modified binding molecules specific for T or B lymphocytes and t

Details Modified binding molecules specific for T or B lymphocytes and t Modified binding molecules specific for T or B lymphocytes and t

1993-01-28

2000-08-22

MacMillan, Keith D.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

5303911, 53038875, 5303896, 5303871, A61K 3940

Patent

active

061068357

ABSTRACT:
Several forms of immunoregulatory substances are derived from monoclonal antibodies (MAbs) that are specific for a T or B cell surface antigen, such as CD3, TCR, CD4, or CD8 on T cells or membrane-bound immunoglobulins on B cells. The substances include: a mixture of F(ab').sub.2 fragments (or other divalent binding molecules which lack Fc) which each bind noncompetitively to different monovalent antigenic epitopes on the same antigen; the F(ab').sub.2 fragment (or other divalent binding molecules which lack Fc) of a bispecific antibody which has each of its binding sites derived from one of the two MAbs that bind noncompetitively to monovalent antigenic epitopes on the same antigen; a conjugate including a polymeric backbone, such as polyethylene glycol ("PEG"), cellulose, dextran, agarose, or an amino acid copolymer or a liposome, that is coupled with the binding molecules, e.g., Fv, Fab, or F(ab').sub.2, which bind noncompetitively to monovalent antigenic epitopes on the same antigen.

REFERENCES:
patent: 4867973 (1989-09-01), Goers et al.
patent: 4925648 (1990-05-01), Hansen et al.
patent: 5024940 (1991-06-01), Brenner et al.
Williams, J.M. et al. J. of Immunol. 135:2249-2255 (1985).
Geppert, T.D. et al. J. of Immunol. 138:1660-1666 (1987).
Ceuppens, J.L. et al. J. of Immunol. 137:1816-1821 (1986).
Rodwell, J.D. et al. Proc. Natl. Acad. Sci. USA 83:2632-2636 (1986).
Brunswick et al. J. Immunol. 140:3364-72 (1988).
Blazer et al. J. Immunol. 147:1492-1503 (1991).
Hirsch et al J. Immunol. 147:2088-93 (1991).
Ellenhorn, J.D.I. Transplantation 50:608-612 (1990).
Richards, J.M. New Engl. Journal. of Med. 323:487 (1990).
Osband, M.E. et al. The Lancet 335:494-498 (1990).
Leo, O. et al. Proc. Natl. Acad. Sci. USA 84:1374-1378 (1987).
Hirsch, R. et al. J. of Immunol. 142:737-743 (1989).
Hirsch, R. et al. Transplantation 47:853-857 (1989).
Hirsch, R. et al. Transplantation 49:1117-1123 (1990).
Hirsch, R. et al. The Lancet (1989).
Kast, W.M. et al. J. of Immunol. 145:2254-2259 (1990).
Ellenhorn, J.D.I. et al. J. of Immunol. 144:2840-2846 (1990).
Ellenhorn, J.D.I. et al. Science 242:569-571 (1988).
Nayersina et al. Abstract from Mechanisms of Tumor Rejection II A1713 #7793 (1991).
Baniyash, M. et al. J. Biological Chem. 263:9874-9878 (1988).
Geisler, C. et al. J. of Immunol. 145:1761-1767 (1990).
Bravehamp et al Anal Biochem 131:25-33 1983.
Huang et al J Biol Chem 1983.
Raith Immunology Gower Medical Publishing 1985 p. 8.7 Fig 8.19.
Williams et al J Immunology 135(4):2249-2255 1985.
Geppert et al J Immunology 138(6):1660-1666 1987.
Verwilghen et al Immunology 72:269-276 1991.
Harris et al TioTech 11:42-46 1993.
Waldmann Science 252:1657-1662 1991.
Hanlow et al Antibodies A Laboratory Manual (1988) Col Spring Hanbon Press p. 626.
Martin et al 136:3282-3287 (1986).
Osband et al Immunology Today 11:193-195 (1990).
Paul Fundamental Immunology Raven Press (1989) p. 364.
Webster's II New Riverside University Dictionary (1988) pp. 738 & 880.

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