Modified .beta..sub.2 -microglobulin

Details Modified .beta..sub.2 -microglobulin Modified .beta..sub.2 -microglobulin

1987-01-15

1991-09-24

Rosen, Sam

Chemistry: analytical and immunological testing

Involving producing or treating antigen or hapten

Producing labeled antigens

436518, 436543, 436544, 436547, 530324, 530386, 530380, 530388, 530389, 530392, 530394, 530403, 530811, 530812, G01N 33534, C07K 1300, C07K 1700

Patent

active

050513710

ABSTRACT:
Substantially pure modified .beta..sub.2 -microglobulin (m.beta..sub.2 m) of the formula I ##STR1## wherein R.sub.1 is 24-amino acid residue, with the sequence Ile-Gln-Arg-Thr-Pro-Lys-Ile-Gln-Val-Tyr-Ser-Arg-His-Pro-Ala-Glu-Asn-Gly-Ly s-Ser-Asn-Phe-Leu-Asn, R.sub.2 is a 30-amino acid residue with the sequence Tyr-Val-Ser-Gly-Phe-His-Pro-Ser-Asp-Ile-Glu-Val-Asp-Leu-Leu-Lys-Asn-Gly-Gl u-Arg-Ile-Gly-Lys-Val-Glu-His-Ser-Asp-Leu-Ser, R.sub.3 is a 20-amino acid residue with the sequence Trp-Ser-Phe-Tyr-Leu-Leu-Tyr-Tyr-Glu-Phe-Thr-Pro-Thr-Glu-Lys-Asp-Glu-Tyr-Al a, R.sub.4 is a 19-amino acid residue with the sequence Arg-Val-Asn-His-Val-Thr-Leu-Ser-Gln-Pro-Lys-Ile-Val-Lys-Trp-Asp-Arg-Asp-Me t, X is Phe, Phe-Ser, or Phe-Ser-Lys, and Y is Asp, Lys-Asp, or Ser-Lys-Asp is disclosed. The presence of the protein in body fluids is a diagnostic and/or prognostic marker for the development of a variety of disorders such as different types of cancer and diseases involving the immune system. Also disclosed are specific anti-m.beta..sub.2 m antibodies used for the detection and quantification of m.beta..sub.2 m.

REFERENCES:
patent: 4264766 (1981-04-01), Fischer
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Suggs et al., Proc. Natl. Acad. Sci. U.S.A., 78:6613-6617 (1981).
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