Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-05-14
2010-06-08
Noakes, Suzanne M. (Department: 1656)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069700
Reexamination Certificate
active
07732586
ABSTRACT:
Modified forms of naturally occurring bacteriocins, such as the R-type pyocins ofPseudomonas aeruginosa, are disclosed. The bacteriocins are modified at the ends of their tail fibers in a region responsible for binding specificity and affinity to their cognate binding partners, or receptors, such as those on the surface of bacteria. Methods for the use of the modified bacteriocins, such as to bind receptors, including virulence or fitness factors, on the surfaces of bacteria, are also described.
REFERENCES:
patent: 4142939 (1979-03-01), Morse et al.
patent: 4861754 (1989-08-01), Farkas-Himsley
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5571698 (1996-11-01), Ladner et al.
patent: 6355411 (2002-03-01), Ausubel et al.
patent: 6818418 (2004-11-01), Lipovsek et al.
patent: 2003/0175207 (2003-09-01), Olstein et al.
patent: 2006/0121450 (2006-06-01), Miller et al.
patent: 2006/0229244 (2006-10-01), Dorit et al.
patent: WO99/16873 (1999-04-01), None
patent: WO99/27129 (1999-06-01), None
patent: WO00/60070 (2000-10-01), None
patent: WO01/01786 (2001-01-01), None
patent: WO2005/46579 (2005-05-01), None
Nakayama et al., The R-type Pyocin ofPseudomonas aeruginosais Related to P2 Phage, and the F-type is Related to Lambda Phage, Mol. Micro., 2000, 38(2): 213-231.
Williams et al., Retargeting T-type Pyocins to Generate Novel Bactericidal Protein ComplexesApp. Eng. Micro. Jun. 2008, 74(12):3868-3876.
Akerley, B.J., et al. “Ectopic expression of the flagellar regulon alters development of theBordetella—host interaction”,Cell(1995) 80:611-620.
Ackermann, H.W. “Bacteriophage observations and evolution”,Res. Microbiol.(2003) 154:245-251.
Aiache, J.M., et al. “The formulation of drug for ocular administration”,J. Biomater Appl.(1997) 11:329-348.
Anisimov, A.P., et al. “Treatment of plague: promising alternatives to antibodies”,Journal of Medical Microbiology(2006) 55:1461-1475.
Anantharaman, et al. “Application of comparative genomics in the identification and analysis of novel families of membrane-associated receptors in bacteria”,BMC Genomics(2003) 4:34.
Bad Bugs, No Drugs: As Antibiotic Discovery Stagnates . . . A Public Health Crisis Brews,Infectious Diseases Society of America(Jul. 2004) pp. 1-35.
Batchelor, M., et al. “Structural basis for recognition of the translocated intimin receptor (Tir) by intimin from enteropathogenicEscherichia coli”,EMBO J.(2000) 19(11):2452-2464.
Bertani, L. E., et al. “The P2-like phages and their parasite, P4”, in R. Calendar (ed.)The Bacteriophages, Plenum Publishing Corp., New York, 2:73-143 (1988).
Beste, G., et al. “Small antibody-like proteins with prescribed ligand specificities derived from the lipocalin fold”,Proc. Natl. Acad. Sci USA(1999) 96:1898-1903.
Birmingham, V.A., et al. “Genetic transformation inStaphylococcus aureus: Isolation and Characterization of a Competence-Conferring Factor from Bacteriophage 80α Lysates”,Journal of Bacteriology(1981) 148:301-307.
Blackwell, C.C., et al. “Sensitivity of thermophilic campylobacters to R-type pyocins ofPseudomonas aeruginosa”,J. Med. Microbiology(1982) 15:247-251.
Bonev, B.B., et al. “Targeting extracellular pyrophosphates underpins the high selectivity of nisin”,The FASEB Journal(2004) 18:1862-1869.
Bowen, Benjamin R., et al. “Characterization of a Human Homologue of the Murine Peripheral Lymph Node Homing Receptor”,The Journal of Cell Biology(1989) 109:421-427.
Bradley, “Ultrastructure of Bacteriophages and Bacteriocins”,Bacteriol. Revs.(1967) 31(4):230-314.
Brazas, M.D., et al. “Ciprofloxacin Induction of a Susceptibility Determinant inPseudomonas aeruginosa”, Antimicrobial Agents and Chemotherapy(2005) 49(8):3222-3227.
Burda, M.R., et al. “Folding of coliphage T4 short tail fiber in vitro. Analysing the role of a bacteriophage-encoded chaperone”,Eur. J. Biochem.(1999) 265(2):771-778.
Calamita, G. “TheEscherichia coliaquaporin-Z water channel”,Molecular Microbiology(2000) 37(2):254-262.
Chappell J.D., et al. “The crystal structure of reovirus attachment protein σ1 reveals evolutionary relationship to adenovirus fiber.”The EMBO Journal(2002) 21(1-2):1-11.
Cheng, K.H., et al. “Incidence of contact lens-associated microbial keratitis and its related morbidity”,Lancet(1999) 354:181-185.
Choi, H.K., et al. “A Tn-7 based broad-range bacterial cloning and expression system”,Nature Methods(2005) 2(6):443-448.
Coetzee, H.E., et al. “Bacteriophage-tail-like particles associated with intra-species killing ofProteus vulgaris”,J. Gen. Virol.(1968) 2:29-36.
Cole, N., et al. “Different Strains ofPseudomonas aeruginosaIsolated From Ocular Infections or Inflammation Display Distinct Corneal Pathologies in an Animal Mode”,Curr. Eye Res.(1998) 17:730-735.
Cooper, R.L., et al. “Infective keratitis in soft contact lens wearers”,Br. J. Ophthalmol(1977) 61:250-254.
Cotter, P.A., et al. “A mutation in theBordetella bronchiseptica bygSgene results in reduced virulence and increased resistance to starvation, and identifies a new class of Bvgregulated antigens”,Mol. Microbiol.(1997) 24(4):671-685.
Cowell, B.A., et al. “Use of an Animal Model in Studies of Bacterial Comeal Infection”,Inst. Lab Animal Res J.(1999) 40(2):43-50.
Curtis, M.D., et al. “Investigation of the specificity of the interaction between colicin E9 and its immunity protein by site-directed mutagenesis”,Molecular Microbiology(1991) 5(11):2727-2733.
Davis, M.M., et al. “T-cell antigen receptor genes and T-cell recognition”,Nature(1988) 334:395-402.
Daw, et al. “Bacteriocins: Nature, Function, Structure”,Micron(1996) 27(6):467-479.
Desplats, C., et al. “The diversity and evolution of the T4-type bacteriophages”,Res Microbiol.(2003) 154(4):259-267.
Doulatov, S., et al. “Tropism switching inBordetellabacteriophage defines a family of diversity-generating retroelements”,Nature(2004) 431:476-481.
Drickamer, Kurt, “Two Distinct Classes of Carbohydrate-recognition Domains in Animal Lectins”,The Journal of Biological Chemistry, (1988) 263(20):9557-9560.
Drickamer, K., et al. “C-type lectin-like domains”,Current Opinion in Structural Biology(1999) 9:585-590.
Dykes, G.A., et al. “Selection and fitness in bacteriocin-producing bacteria”,Proc. R. Soc. Lond.B (1997) 264:683-687.
Emsley, P., et al. “Crystallographic characterization of pertactin, a membrane-associated protein fromBordetella pertussis”,J. Mol. Biol(1994) 235:772-773.
Emsley, P., et al. “Structure ofBordetella pertussisvirulence factor P.69 pertactin”,Nature(1996) 381:90-92.
Farmer, III, J. J., et al. “Epidemiologic Fingerprinting ofPseudomonas aeruginosaby the Production of and Sensitivity to Pyocin and Bacteriophage”,Applied Microbiol.18(5):760-765.
Filiatrault, M.J., et al. “Construction and Characterization ofHaemophilus ducreyiLipooligosaccharide (LOS) Mutants Defective in Expression of Heptosyltransferase III and β1,4-Glucosyltransferase: Identification of LOS Glycoforms Containing Lactosamine Repeats”,Infection and Immunity(2000) 68(6):3352-3361.
Filiatrault, M.J., et al. “Genetic Analysis of a Pyocin-Resistant Lipooligosaccharide (LOS) Mutant ofHaemophilus ducreyi: Restoration of Full-Length LOS Restores Pyocin Sensitivity”,Journal of Bacteriology(2001) 183(19):5756-5761.
Fleiszig, S.M.J., et al. “The pathogenesis of bacterial keratitis: studies withPseudomonas aeruginosa”,Clin Exp Optom.(2002) 85.5:271-278.
Gerke, J.R., et al. “ExperimentalPseudomonas aeruginosainfection of the mouse cornea”,Infect. Immun.(1971) 3(2):209-216.
Gillor, Osnat, et al. “Genetically Engineered Bacteriocins and their Potential as the Next Generation
Jamieson Andrew C.
Martin, Jr. David W.
Scholl Dean M.
Williams Steven R.
AvidBiotics Corporation
Noakes Suzanne M.
Sughrue & Mion, PLLC
LandOfFree
Modified bacteriocins and methods for their use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modified bacteriocins and methods for their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified bacteriocins and methods for their use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4182513