Modified antibody fragments

Details Modified antibody fragments Modified antibody fragments

2006-07-17

2011-11-08

Yu, Misook (Department: 1643)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S391100

Reexamination Certificate

active

08053562

ABSTRACT:
The present invention relates to a new class of modified antibody fragments. The present invention provides an antibody fragment to which one or more effector molecules is attached characterized in that the native interchain disulphide bond between the heavy (CHI) and light (CL) chain constant regions is absent and the heavy chain (CHI) and light chain (CL) constant regions are linked by an interchain disulphide bond between a pair of engineered cysteines, one in the light chain constant (CL) region and the other in the heavy chain constant (CHI) region.

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Rothlisberger et al (JMB, 347-773-789, 2005).
Poljak et al (PNAS 70(12):3305-3310, 1973).

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