Modified antibody fab fragments

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S387300, C530S388100, C530S391100, C424S130100, C424S133100, C424S141100, C424S178100, C424S179100

Reexamination Certificate

active

07989594

ABSTRACT:
The present invention provides antibody Fab fragments in which the heavy chain constant region terminates at the interchain cysteine of CH1. Also provided are antibody Fab fragments in which the heavy chain constant region terminates at the interchain cysteine of CH1 to which one or more effector molecules are attached.

REFERENCES:
patent: WO89/01974 (1989-03-01), None
patent: WO93/06217 (1993-04-01), None
patent: 98/25971 (1998-06-01), None
patent: WO 03/074679 (2003-09-01), None
Pritsch et al. J. Clin. Invest. 1996 98;10:2235-2243.
Vitetta et al. Science 2006 313:308-309.
Chapman et al. Nature Biotechnology, 1999 17:780-783.
Singh, Rajeeva et al., “Labeling of Antibodies by in situ Modification of Thiol Groups Generated from Selenol-Catalyzed Reduction of Native Disulfide Bonds”, Analytical Biochemistry, vol. 304, No. 2, May 15, 2002, pp. 147-156.
Leong, S. R. et al., “Adapting Pharmacokinetic Properties of a Humanized Anti-Interleukin-8 Antibody for Therapeutic Applications Using Site-Specific Pegylation”, Cytokine, 2001, 16(3), 106-119.
Tout, N. L. et al., “Phage Display and Bacterial Expression of a Recombinant Fab Specific for Pseudomonas Aeruginosa Serotype O6 Lipopolysaccharide”, Clinical and Diagnostic Laboratory Immunology, 1997, 4(2), 147-155.
Khawli, L. A. et al., “Stable, Genetically Engineered F(ab')2 Fragments of Chimeric TNT-3 Expressed in Mammalian Cells”, Hybridoma and Hybridomics, 2002, 21(1), 11-18.
Alfthan, K. et al., “Efficient Secretion of Murine Fab Fragments byEscherichia coliis Determined by the First Constant Domain of the Heavy Chain”, Gene., 1993, vol. 128, 203-209.
Wels, J. A. et al., Definition of Mouse gene IgG-3 heavy chain constant region, GenBank Acc. No. X00915, published Nov. 14, 2006 at http://www.ncbi.nlm.nih.gov
uccore/51816, 3 sheets.
http://en.wikipedia.org/wiki/File :Engineered—monoclonal—antibodies. Svg, printed on Dec. 10, 2010, 1 sheet.
Chapman, “PEGylated antibodies and antibody fragments for improved therapy: a review”, Advanced Drug Delivery Reviews, 54 (2002) 531-545.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Modified antibody fab fragments does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modified antibody fab fragments, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified antibody fab fragments will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2746318

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.