Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1993-08-25
1994-11-22
Lacey, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303917, 5303871, 5303884, C07K 1528
Patent
active
053670582
ABSTRACT:
The present invention relates to modified antibodies and fragments which display an increased affinity for antigen as compared to the affinity of unmodified antibody for antigen. The most preferred modification is the addition of a thiol group on the surface of the antibody such that a covalent bond forms between the antibody and antigen when they bind to one another.
REFERENCES:
patent: 5215889 (1993-06-01), Schultz
Pollack, S. J. et al. Science 242, 1038-1040 (1988).
Linn Jr. C. Preston
Mize Patrick D.
Pitner J. Bruce
Becton Dickinson and Company
Highet David W.
Lacey David L.
Loring Susan A.
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