Modified antibodies for enhanced hepatocyte clearance

Details Modified antibodies for enhanced hepatocyte clearance Modified antibodies for enhanced hepatocyte clearance

1987-09-14

1989-08-22

Warden, Robert J.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

128653, 128654, 136173, 136806, 530387, 530388, 530389, 530395, 530396, 530402, A61K 4900

Patent

active

048594490

ABSTRACT:
Antibodies and antibody conjugates which have been modified by conjugation to, or exposure thereon, of glycoside residues that bind to the human hepatic asialoglycoprotein receptor clear rapidly from the circulation. Use of such modified antibodies and antibody conjugates for imaging and therapy of tumors and infectious lesions is advantageous when the antibodies are administered by a regional route, or when intravenous administration is accompanied by injection of a competitive hepatic lectin binding inhibitor to control the rate of clearance and optimize uptake by the target tissues.

REFERENCES:
patent: 4624846 (1986-11-01), Goldenberg
Perry et al. Biological Abstracts, vol. 77, 1984 #84414.
Winkelhake et al, J. Biol. Chem. 251(4), 1074-1080, 1976.

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