Modified antibiotic resistance gene

Details Modified antibiotic resistance gene Modified antibiotic resistance gene

1988-05-31

1990-10-02

Mays, Thomas D.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4351723, 435194, 435320, 536 27, 935 14, 935 29, 935 69, 935 73, C12N 120, C12N 1500, C12N 912, C07H 1512

Patent

active

049607049

ABSTRACT:
A modified hygromycin B resistance-conferring gene either alone or in translational reading phase with a gene or portion of a gene is disclosed. The invention further comprises recombinant DNA cloning vectors and transformants of the aforementioned DNA.

REFERENCES:
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Kaster et al, 1983, "Analysis of a Bacterial Hygromycin B Resistance Gene by Transcriptional and Translational Fusions and by DNA Seq." Nuc. Acids Res., vol. 11, No. 19, pp. 6895-6911.
Casadaban et al., 1980, "In Vitro Gene Fusions That Join an Enzymatically Active .beta.-Galactosidase Segment to Amino-Terminal Fragments of Exagenous Proteins . . . " J. Bact., vol. 143, pp. 971-980.
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Davies et al., 1978, "Enzyme Modification of Aminoglycoside Antibiotics: 3-N-Acetyltransferase with Broad Specificity . . . " Antimicrob. Agents Chemother., vol. 14(1), 69-72, in: Chem. Abstracts, vol. 89, Abstr. No. 159954y.
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